Novel Osteogenic Ti-6Al-4V Device For Restoration Of Dental Function In Patients With Large Bone Deficiencies: Design, Development And Implementation
Custom devices supporting bone regeneration and implant placement are needed for edentulous patients with large mandibular deficiencies where endosteal implantation is not possible. We developed a novel subperiosteal titanium-aluminum-vanadium bone onlay device produced by additive manufacturing (AM...
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| Veröffentlicht in: | Scientific reports 2016-02, Vol.6 (1), p.20493-20493, Article 20493 |
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| creator | Cohen, D. J. Cheng, A. Kahn, A. Aviram, M. Whitehead, A. J. Hyzy, S. L. Clohessy, R. M. Boyan, B. D. Schwartz, Z. |
| description | Custom devices supporting bone regeneration and implant placement are needed for edentulous patients with large mandibular deficiencies where endosteal implantation is not possible. We developed a novel subperiosteal titanium-aluminum-vanadium bone onlay device produced by additive manufacturing (AM) and post-fabrication osteogenic micro-/nano-scale surface texture modification. Human osteoblasts produced osteogenic and angiogenic factors when grown on laser-sintered nano-/micro-textured surfaces compared to smooth surfaces. Surface-processed constructs caused higher bone-to-implant contact, vertical bone growth into disk pores (microCT and histomorphometry) and mechanical pull-out force at 5 and 10 w on rat calvaria compared to non surface-modified constructs, even when pre-treating the bone to stimulate osteogenesis. Surface-modified wrap-implants placed around rabbit tibias osseointegrated by 6 w. Finally, patient-specific constructs designed to support dental implants produced via AM and surface-processing were implanted on edentulous mandibular bone. 3 and 8 month post-operative images showed new bone formation and osseointegration of the device and indicated stability of the dental implants. |
| doi_str_mv | 10.1038/srep20493 |
| format | Article |
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J. ; Cheng, A. ; Kahn, A. ; Aviram, M. ; Whitehead, A. J. ; Hyzy, S. L. ; Clohessy, R. M. ; Boyan, B. D. ; Schwartz, Z.</creator><creatorcontrib>Cohen, D. J. ; Cheng, A. ; Kahn, A. ; Aviram, M. ; Whitehead, A. J. ; Hyzy, S. L. ; Clohessy, R. M. ; Boyan, B. D. ; Schwartz, Z.</creatorcontrib><description>Custom devices supporting bone regeneration and implant placement are needed for edentulous patients with large mandibular deficiencies where endosteal implantation is not possible. We developed a novel subperiosteal titanium-aluminum-vanadium bone onlay device produced by additive manufacturing (AM) and post-fabrication osteogenic micro-/nano-scale surface texture modification. Human osteoblasts produced osteogenic and angiogenic factors when grown on laser-sintered nano-/micro-textured surfaces compared to smooth surfaces. Surface-processed constructs caused higher bone-to-implant contact, vertical bone growth into disk pores (microCT and histomorphometry) and mechanical pull-out force at 5 and 10 w on rat calvaria compared to non surface-modified constructs, even when pre-treating the bone to stimulate osteogenesis. Surface-modified wrap-implants placed around rabbit tibias osseointegrated by 6 w. Finally, patient-specific constructs designed to support dental implants produced via AM and surface-processing were implanted on edentulous mandibular bone. 3 and 8 month post-operative images showed new bone formation and osseointegration of the device and indicated stability of the dental implants.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep20493</identifier><identifier>PMID: 26854193</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>13/107 ; 631/61/54/993 ; 692/700/3032/3065/3070 ; Alloys ; Aluminum ; Angiogenesis ; Animals ; Biocompatible Materials - chemistry ; Biocompatible Materials - pharmacology ; Bone growth ; Bone histomorphometry ; Bone implants ; Bone Screws ; Calvaria ; Cell Line ; Computed tomography ; Dental Implants ; Dental prosthetics ; Dental restorative materials ; Equipment Design ; Fabrication ; Humanities and Social Sciences ; Humans ; Male ; Mandible ; multidisciplinary ; Osseointegration ; Osseointegration - drug effects ; Osteoblasts ; Osteoblasts - cytology ; Osteoblasts - metabolism ; Osteogenesis ; Osteogenesis - drug effects ; Porosity ; Rabbits ; Rats ; Rats, Nude ; Rats, Sprague-Dawley ; Regeneration ; Science ; Skull - diagnostic imaging ; Skull - drug effects ; Skull - pathology ; Surface Properties ; Tibia - diagnostic imaging ; Tibia - drug effects ; Tibia - pathology ; Titanium ; Titanium - chemistry ; Titanium - pharmacology ; Vanadium</subject><ispartof>Scientific reports, 2016-02, Vol.6 (1), p.20493-20493, Article 20493</ispartof><rights>The Author(s) 2016</rights><rights>Copyright Nature Publishing Group Feb 2016</rights><rights>Copyright © 2016, Macmillan Publishers Limited 2016 Macmillan Publishers Limited</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-f3839095efec701d00284e370a3654f5a0e40fb6fce6cfbcb5c58e0312f6cd043</citedby><cites>FETCH-LOGICAL-c438t-f3839095efec701d00284e370a3654f5a0e40fb6fce6cfbcb5c58e0312f6cd043</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745084/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745084/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26854193$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cohen, D. J.</creatorcontrib><creatorcontrib>Cheng, A.</creatorcontrib><creatorcontrib>Kahn, A.</creatorcontrib><creatorcontrib>Aviram, M.</creatorcontrib><creatorcontrib>Whitehead, A. J.</creatorcontrib><creatorcontrib>Hyzy, S. L.</creatorcontrib><creatorcontrib>Clohessy, R. M.</creatorcontrib><creatorcontrib>Boyan, B. D.</creatorcontrib><creatorcontrib>Schwartz, Z.</creatorcontrib><title>Novel Osteogenic Ti-6Al-4V Device For Restoration Of Dental Function In Patients With Large Bone Deficiencies: Design, Development And Implementation</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Custom devices supporting bone regeneration and implant placement are needed for edentulous patients with large mandibular deficiencies where endosteal implantation is not possible. We developed a novel subperiosteal titanium-aluminum-vanadium bone onlay device produced by additive manufacturing (AM) and post-fabrication osteogenic micro-/nano-scale surface texture modification. Human osteoblasts produced osteogenic and angiogenic factors when grown on laser-sintered nano-/micro-textured surfaces compared to smooth surfaces. Surface-processed constructs caused higher bone-to-implant contact, vertical bone growth into disk pores (microCT and histomorphometry) and mechanical pull-out force at 5 and 10 w on rat calvaria compared to non surface-modified constructs, even when pre-treating the bone to stimulate osteogenesis. Surface-modified wrap-implants placed around rabbit tibias osseointegrated by 6 w. 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J.</au><au>Cheng, A.</au><au>Kahn, A.</au><au>Aviram, M.</au><au>Whitehead, A. J.</au><au>Hyzy, S. L.</au><au>Clohessy, R. M.</au><au>Boyan, B. D.</au><au>Schwartz, Z.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Novel Osteogenic Ti-6Al-4V Device For Restoration Of Dental Function In Patients With Large Bone Deficiencies: Design, Development And Implementation</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2016-02-08</date><risdate>2016</risdate><volume>6</volume><issue>1</issue><spage>20493</spage><epage>20493</epage><pages>20493-20493</pages><artnum>20493</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Custom devices supporting bone regeneration and implant placement are needed for edentulous patients with large mandibular deficiencies where endosteal implantation is not possible. We developed a novel subperiosteal titanium-aluminum-vanadium bone onlay device produced by additive manufacturing (AM) and post-fabrication osteogenic micro-/nano-scale surface texture modification. Human osteoblasts produced osteogenic and angiogenic factors when grown on laser-sintered nano-/micro-textured surfaces compared to smooth surfaces. Surface-processed constructs caused higher bone-to-implant contact, vertical bone growth into disk pores (microCT and histomorphometry) and mechanical pull-out force at 5 and 10 w on rat calvaria compared to non surface-modified constructs, even when pre-treating the bone to stimulate osteogenesis. Surface-modified wrap-implants placed around rabbit tibias osseointegrated by 6 w. Finally, patient-specific constructs designed to support dental implants produced via AM and surface-processing were implanted on edentulous mandibular bone. 3 and 8 month post-operative images showed new bone formation and osseointegration of the device and indicated stability of the dental implants.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>26854193</pmid><doi>10.1038/srep20493</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 13/107 631/61/54/993 692/700/3032/3065/3070 Alloys Aluminum Angiogenesis Animals Biocompatible Materials - chemistry Biocompatible Materials - pharmacology Bone growth Bone histomorphometry Bone implants Bone Screws Calvaria Cell Line Computed tomography Dental Implants Dental prosthetics Dental restorative materials Equipment Design Fabrication Humanities and Social Sciences Humans Male Mandible multidisciplinary Osseointegration Osseointegration - drug effects Osteoblasts Osteoblasts - cytology Osteoblasts - metabolism Osteogenesis Osteogenesis - drug effects Porosity Rabbits Rats Rats, Nude Rats, Sprague-Dawley Regeneration Science Skull - diagnostic imaging Skull - drug effects Skull - pathology Surface Properties Tibia - diagnostic imaging Tibia - drug effects Tibia - pathology Titanium Titanium - chemistry Titanium - pharmacology Vanadium |
| title | Novel Osteogenic Ti-6Al-4V Device For Restoration Of Dental Function In Patients With Large Bone Deficiencies: Design, Development And Implementation |
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