Sesamol decreases melanin biosynthesis in melanocyte cells and zebrafish: Possible involvement of MITF via the intracellular cAMP and p38/JNK signalling pathways

The development of antimelanogenic agents is important for the prevention of serious aesthetic problems such as melasma, freckles, age spots and chloasma. The aim of this study was to investigate the antimelanogenic effect of sesamol, an active lignan isolated from Sesamum indicum, in melan‐a cells....

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Veröffentlicht in:	Experimental dermatology 2015-10, Vol.24 (10), p.761-766
Hauptverfasser:	Baek, Seung-hwa, Lee, Sang-Han
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antimelanogenic agents Antioxidants - pharmacology Benzodioxoles - pharmacology cyclic adenosine monophosphate Cyclic AMP - metabolism Dose-Response Relationship, Drug Down-Regulation Gene Expression - drug effects Intramolecular Oxidoreductases - genetics JNK Mitogen-Activated Protein Kinases - metabolism Melanins - biosynthesis Melanocytes - drug effects Melanocytes - metabolism microphthalmia-associated transcription factor Microphthalmia-Associated Transcription Factor - genetics Monophenol Monooxygenase - genetics Monophenol Monooxygenase - metabolism Original Oxidoreductases - genetics p38 Mitogen-Activated Protein Kinases - metabolism Phenols - pharmacology Phosphorylation - drug effects Pigmentation - drug effects Protein Biosynthesis - drug effects Receptor, Melanocortin, Type 1 - genetics sesamol tyrosinase Zebrafish
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