Expression of the miR‐302/367 cluster in glioblastoma cells suppresses tumorigenic gene expression patterns and abolishes transformation related phenotypes

Cellular transformation is initiated by the activation of oncogenes and a closely associated developmental reprogramming of the epigenetic landscape. Transcription factors, regulators of chromatin states and microRNAs influence cell fates in development and stabilize the phenotypes of normal, differ...

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Veröffentlicht in:	International journal of cancer 2015-11, Vol.137 (10), p.2296-2309
Hauptverfasser:	Yang, Chul Min, Chiba, Tomohiro, Brill, Boris, Delis, Natalia, von Manstein, Viktoria, Vafaizadeh, Vida, Oellerich, Thomas, Groner, Bernd
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Animals Brain Neoplasms - genetics Brain Neoplasms - metabolism Brain Neoplasms - pathology Cancer Cancer Cell Biology Cancer therapies Cell activation Cell differentiation Cell Line, Tumor Cell migration Cell Movement Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Cell Transformation, Neoplastic - pathology Cellular Reprogramming Chromatin Cytokines - metabolism Embryo cells Embryogenesis epigenetic regulation of the tumor cell state Epigenetics Gene expression Gene Expression Regulation, Neoplastic Genetic transformation Glioblastoma Glioblastoma - genetics Glioblastoma - metabolism Glioblastoma - pathology Glioblastoma cells Glioma Hepatocytes Humans KLF4 protein Medical research Metastases Metastasis Mice Mice, Nude MicroRNAs - genetics miRNA miR‐302/367 regulated gene expression Myc protein Neoplasm Transplantation Olig2 protein Phenotypes Stem cells Transcription activation Transcription factors Transcription Factors - metabolism Tumor cells tumor suppression
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