Diverse and Targetable Kinase Alterations Drive Histiocytic Neoplasms

Histiocytic neoplasms are clonal, hematopoietic disorders characterized by an accumulation of abnormal, monocyte-derived dendritic cells or macrophages in Langerhans cell histiocytosis (LCH) and non-Langerhans cell histiocytosis (non-LCH), respectively. The discovery of BRAF(V600E) mutations in appr...

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Veröffentlicht in:	Cancer discovery 2016-02, Vol.6 (2), p.154-165
Hauptverfasser:	Diamond, Eli L, Durham, Benjamin H, Haroche, Julien, Yao, Zhan, Ma, Jing, Parikh, Sameer A, Wang, Zhaoming, Choi, John, Kim, Eunhee, Cohen-Aubart, Fleur, Lee, Stanley Chun-Wei, Gao, Yijun, Micol, Jean-Baptiste, Campbell, Patrick, Walsh, Michael P, Sylvester, Brooke, Dolgalev, Igor, Aminova, Olga, Heguy, Adriana, Zappile, Paul, Nakitandwe, Joy, Ganzel, Chezi, Dalton, James D, Ellison, David W, Estrada-Veras, Juvianee, Lacouture, Mario, Gahl, William A, Stephens, Philip J, Miller, Vincent A, Ross, Jeffrey S, Ali, Siraj M, Briggs, Samuel R, Fasan, Omotayo, Block, Jared, Héritier, Sebastien, Donadieu, Jean, Solit, David B, Hyman, David M, Baselga, José, Janku, Filip, Taylor, Barry S, Park, Christopher Y, Amoura, Zahir, Dogan, Ahmet, Emile, Jean-Francois, Rosen, Neal, Gruber, Tanja A, Abdel-Wahab, Omar
Format:	Artikel
Sprache:	eng
Schlagworte:	Gene Expression Profiling - methods Histiocytosis, Langerhans-Cell - drug therapy Histiocytosis, Langerhans-Cell - enzymology Histiocytosis, Langerhans-Cell - genetics Histiocytosis, Non-Langerhans-Cell - drug therapy Histiocytosis, Non-Langerhans-Cell - enzymology Histiocytosis, Non-Langerhans-Cell - genetics Humans MAP Kinase Kinase 1 - genetics MAP Kinase Signaling System - drug effects Mutation Protein Kinase Inhibitors - therapeutic use Proto-Oncogene Proteins B-raf - genetics Receptor Protein-Tyrosine Kinases - genetics Receptor, trkA - genetics Sequence Analysis, DNA - methods
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