sciReptor: analysis of single-cell level immunoglobulin repertoires

The sequencing of immunoglobulin (Ig) transcripts from single B cells yields essential information about Ig heavy:light chain pairing, which is lost in conventional bulk sequencing experiments. The previously limited throughput of single-cell approaches has recently been overcome by the introduction...

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Veröffentlicht in:	BMC bioinformatics 2016-02, Vol.17 (44), p.67-67, Article 67
Hauptverfasser:	Imkeller, Katharina, Arndt, Peter F, Wardemann, Hedda, Busse, Christian E
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Annotations Antigens B cells Computational Biology - methods Design Flow cytometry Genes, Immunoglobulin Genetic aspects High-Throughput Nucleotide Sequencing - methods Humans Immunoglobulins Immunoglobulins - genetics Immunology Light Metadata Molecular Sequence Annotation Polymerase chain reaction Quality control Receptors, Immunologic - genetics Relational data bases Single-Cell Analysis - methods Software T cell receptors
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