Protection from Radiation-Induced Pulmonary Fibrosis by Peripheral Targeting of Cannabinoid Receptor-1

Radiation-induced pulmonary fibrosis (RIF) is a severe complication of thoracic radiotherapy that limits its dose, intensity, and duration. The contribution of the endocannabinoid signaling system in pulmonary fibrogenesis is not known. Using a well-established mouse model of RIF, we assessed the in...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 2015-10, Vol.53 (4), p.555-562
Hauptverfasser:	Bronova, Irina, Smith, Brett, Aydogan, Bulent, Weichselbaum, Ralph R, Vemuri, Kiran, Erdelyi, Katalin, Makriyannis, Alex, Pacher, Pal, Berdyshev, Evgeny V
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cancer Cancer therapies Collagen Drug dosages Drug Evaluation, Preclinical Female Gene Deletion Inflammation Mice, Inbred C57BL Morpholines - pharmacology Morpholines - therapeutic use Mortality Original Research Pulmonary arteries Pulmonary fibrosis Pulmonary Fibrosis - metabolism Pulmonary Fibrosis - prevention & control Pyrazoles - pharmacology Pyrazoles - therapeutic use Radiation Injuries, Experimental - metabolism Radiation Injuries, Experimental - prevention & control Radiation therapy Radiation Tolerance Radiation-Protective Agents - pharmacology Radiation-Protective Agents - therapeutic use Receptor, Cannabinoid, CB1 - antagonists & inhibitors Receptor, Cannabinoid, CB1 - genetics Receptor, Cannabinoid, CB1 - metabolism Rodents Studies
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