Unbalanced recovery of regulatory and effector T cells after allogeneic stem cell transplantation contributes to chronic GVHD

The development and maintenance of immune tolerance after allogeneic hematopoietic stem cell transplantation (HSCT) requires the balanced reconstitution of donor-derived CD4 regulatory T cells (CD4Tregs) as well as effector CD4 (conventional CD4 T cells [CD4Tcons]) and CD8 T cells. To characterize t...

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Veröffentlicht in:	Blood 2016-02, Vol.127 (5), p.646-657
Hauptverfasser:	Alho, Ana C., Kim, Haesook T., Chammas, Marie J., Reynolds, Carol G., Matos, Tiago R., Forcade, Edouard, Whangbo, Jennifer, Nikiforow, Sarah, Cutler, Corey S., Koreth, John, Ho, Vincent T., Armand, Philippe, Antin, Joseph H., Alyea, Edwin P., Lacerda, Joao F., Soiffer, Robert J., Ritz, Jerome
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - pathology CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - pathology Chronic Disease Female Graft vs Host Disease - etiology Graft vs Host Disease - immunology Graft vs Host Disease - pathology Hematopoietic Stem Cell Transplantation - adverse effects Humans Male Middle Aged T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - pathology Transplantation Transplantation, Homologous - adverse effects Young Adult
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