IGF-1 Receptor Differentially Regulates Spontaneous and Evoked Transmission via Mitochondria at Hippocampal Synapses

The insulin-like growth factor-1 receptor (IGF-1R) signaling is a key regulator of lifespan, growth, and development. While reduced IGF-1R signaling delays aging and Alzheimer’s disease progression, whether and how it regulates information processing at central synapses remains elusive. Here, we sho...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2016-02, Vol.89 (3), p.583-597
Hauptverfasser:	Gazit, Neta, Vertkin, Irena, Shapira, Ilana, Helm, Martin, Slomowitz, Edden, Sheiba, Maayan, Mor, Yael, Rizzoli, Silvio, Slutsky, Inna
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Animals Calcium - metabolism Cells, Cultured Excitatory Postsynaptic Potentials - physiology Hippocampus - cytology Hippocampus - physiology Insulin-Like Growth Factor I - physiology Kinases Ligands Mice Miniature Postsynaptic Potentials - physiology Mitochondria - metabolism Neurogenesis Neuronal Plasticity - physiology Neurons Neurons - metabolism Neurosciences Presynaptic Terminals - metabolism Primary Cell Culture Receptor, IGF Type 1 - antagonists & inhibitors Receptor, IGF Type 1 - deficiency Receptor, IGF Type 1 - metabolism Rodents Signal Transduction - physiology Synapses - metabolism Synaptic Transmission - physiology Synaptic Vesicles - metabolism
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