RAGE mediated intracellular Aβ uptake contributes to the breakdown of tight junction in retinal pigment epithelium

Intracellular amyloid beta (Aβ) has been implicated in neuronal cell death in Alzheimer's disease (AD). Intracellular Aβ also contributes to tight junction breakdown of retinal pigment epithelium (RPE) in age-related macular degeneration (AMD). Although Aβ is predominantly secreted from neurona...

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Veröffentlicht in:	Oncotarget 2015-11, Vol.6 (34), p.35263-35273
Hauptverfasser:	Park, Sung Wook, Kim, Jin Hyoung, Park, Sang Min, Moon, Minho, Lee, Ki Hwang, Park, Kyu Hyung, Park, Woo Jin, Kim, Jeong Hun
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid beta-Peptides - metabolism Amyloid beta-Peptides - pharmacology Animals Cells, Cultured Humans Macular Degeneration - genetics Macular Degeneration - metabolism Macular Degeneration - pathology Male MAP Kinase Signaling System Mice Mice, Inbred C57BL Receptor for Advanced Glycation End Products - blood Receptor for Advanced Glycation End Products - metabolism Research Paper: Gerotarget (Focus on Aging) Retinal Pigment Epithelium - metabolism Retinal Pigment Epithelium - pathology Signal Transduction Tight Junctions - metabolism Tight Junctions - pathology
Online-Zugang:	Volltext
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