MiR-744 increases tumorigenicity of pancreatic cancer by activating Wnt/β-catenin pathway

The Wnt/β-catenin signaling pathway, commonly hyperactivated in pancreatic cancer, has been reported to play an important role in the maintenance of stemness of cancer stem cells (CSCs), which is closely related to the progression of pancreatic cancer. Therefore, exploring the regulatory mechanism i...

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Veröffentlicht in:	Oncotarget 2015-11, Vol.6 (35), p.37557-37569
Hauptverfasser:	Zhou, Wei, Li, Yongfeng, Gou, Shanmiao, Xiong, Jiongxin, Wu, Heshui, Wang, Chunyou, Yan, Haijiao, Liu, Tao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta Catenin - genetics beta Catenin - metabolism Blotting, Western Cell Differentiation Disease Progression Female Flow Cytometry Gene Expression Regulation, Neoplastic Glycogen Synthase Kinase 3 - genetics Glycogen Synthase Kinase 3 - metabolism Glycogen Synthase Kinase 3 beta Humans Mice Mice, Inbred BALB C Mice, Nude MicroRNAs - genetics Neoplasm Staging Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Pancreatic Neoplasms - genetics Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - mortality Pancreatic Neoplasms - pathology Prognosis Real-Time Polymerase Chain Reaction Research Paper Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Survival Rate Tumor Cells, Cultured Up-Regulation Wnt Proteins - genetics Wnt Proteins - metabolism Xenograft Model Antitumor Assays
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