MicroRNA-506 suppresses tumor proliferation and metastasis in colon cancer by directly targeting the oncogene EZH2

Increasing evidence reveals that aberrant expression of microRNA contributes to the development and progression of colon cancer, but the roles of microRNA-506 (miR-506) in colon cancer remain elusive. Here, we demonstrated that miR-506 was down-regulated in colon cancer tissue and cells and that miR...

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Veröffentlicht in:	Oncotarget 2015-10, Vol.6 (32), p.32586-32601
Hauptverfasser:	Zhang, Yi, Lin, Changwei, Liao, Guoqing, Liu, Sheng, Ding, Jie, Tang, Fang, Wang, Zhenran, Liang, Xingsi, Li, Bo, Wei, Yangchao, Huang, Qi, Li, Xuan, Tang, Bo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Animals Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Cell Movement Cell Proliferation Colonic Neoplasms - enzymology Colonic Neoplasms - genetics Colonic Neoplasms - mortality Colonic Neoplasms - pathology Colonic Neoplasms - therapy Enhancer of Zeste Homolog 2 Protein Female Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic HCT116 Cells HEK293 Cells HT29 Cells Humans Kaplan-Meier Estimate Lymphatic Metastasis Male Mice, Inbred BALB C Mice, Nude MicroRNAs - genetics MicroRNAs - metabolism Middle Aged Neoplasm Metastasis Neoplasm Staging Polycomb Repressive Complex 2 - genetics Polycomb Repressive Complex 2 - metabolism Research Paper RNA Interference Time Factors Transfection Treatment Outcome Wnt Signaling Pathway
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