POL5551, a novel and potent CXCR4 antagonist, enhances sensitivity to chemotherapy in pediatric ALL

The importance of the cell surface receptor CXCR4 and the chemokine stromal cell-derived factor-1 (SDF-1/CXCL12) is well-established in normal and malignant hematopoiesis. The Protein Epitope Mimetic POL5551 is a novel and potent antagonist of CXCR4. POL5551 efficiently mobilizes hematopoietic stem...

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Veröffentlicht in:	Oncotarget 2015-10, Vol.6 (31), p.30902-30918
Hauptverfasser:	Sison, Edward Allan R, Magoon, Daniel, Li, Li, Annesley, Colleen E, Romagnoli, Barbara, Douglas, Garry J, Tuffin, Gerald, Zimmermann, Johann, Brown, Patrick
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Cell Movement - drug effects Cell Proliferation - drug effects Chemotaxis - drug effects Child Drug Resistance, Neoplasm - drug effects Flow Cytometry Humans Mice Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology Proteins - pharmacology Receptors, CXCR4 - antagonists & inhibitors Research Paper Stromal Cells - drug effects Stromal Cells - metabolism Stromal Cells - pathology Tumor Cells, Cultured Xenograft Model Antitumor Assays
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