Endothelial tyrosine kinase receptor B prevents VE-cadherin cleavage and protects against atherosclerotic lesion development in ApoE-/- mice

Tyrosine kinase receptor B (TrkB) is a high-affinity receptor for brain-derived neurotrophic factor (BDNF). In addition to its nervous system functions, TrkB is also expressed in the aortic endothelium. However, the effects of endothelial TrkB signaling on atherosclerosis remained unknown. Immunoflu...

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Veröffentlicht in:	Oncotarget 2015-10, Vol.6 (31), p.30640-30649
Hauptverfasser:	Jiang, Hong, Huang, Shuhong, Li, Xinyun, Li, Xian, Huang, Shanying, Zhang, Yun, Chen, Zhe-Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD - metabolism Aorta - metabolism Aorta - pathology Apolipoproteins E - genetics Atherosclerosis - prevention & control Brain-Derived Neurotrophic Factor - metabolism Cadherins - metabolism Cells, Cultured Endothelial Cells - metabolism Endothelium, Vascular - pathology Inflammation - immunology Lipids Macrophages - immunology Male Membrane Glycoproteins - biosynthesis Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Mice Mice, Inbred C57BL Mice, Knockout Plaque, Atherosclerotic - prevention & control Protein-Tyrosine Kinases - biosynthesis Protein-Tyrosine Kinases - genetics Protein-Tyrosine Kinases - metabolism Receptor, trkB Research Paper: Pathology RNA Interference RNA, Small Interfering - genetics Signal Transduction Tight Junctions - physiology
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