Systemic delivery of HER2-retargeted oncolytic-HSV by mesenchymal stromal cells protects from lung and brain metastases

Fully retargeted oncolytic herpes simplex viruses (o-HSVs) gain cancer-specificity from redirection of tropism to cancer-specific receptors, and are non-attenuated. To overcome the hurdles of systemic delivery, and enable oncolytic viruses (o-viruses) to reach metastatic sites, carrier cells are bei...

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Veröffentlicht in:	Oncotarget 2015-10, Vol.6 (33), p.34774-34787
Hauptverfasser:	Leoni, Valerio, Gatta, Valentina, Palladini, Arianna, Nicoletti, Giordano, Ranieri, Dario, Dall'Ora, Massimiliano, Grosso, Valentina, Rossi, Martina, Alviano, Francesco, Bonsi, Laura, Nanni, Patrizia, Lollini, Pier-Luigi, Campadelli-Fiume, Gabriella
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain Neoplasms - secondary Breast Neoplasms - pathology Female Flow Cytometry Humans Lung Neoplasms - secondary Mesenchymal Stem Cell Transplantation - methods Mesenchymal Stromal Cells - virology Mice Mice, Nude Neoplasm Metastasis - prevention & control Oncolytic Virotherapy - methods Oncolytic Viruses Ovarian Neoplasms - pathology Receptor, ErbB-2 - metabolism Research Paper Simplexvirus Xenograft Model Antitumor Assays
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