IgE-tailpiece associates with α-1-antitrypsin (A1AT) to protect IgE from proteolysis without compromising its ability to interact with FcεRI

Several splice variants of IgE exist in human plasma, including a variant called IgE-tailpiece (IgE-tp) that differs from classical IgE by the replacement of two carboxy-terminal amino acids with eight novel residues that include an ultimate cysteine. To date, the role of the secreted IgE-tp isoform...

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Veröffentlicht in:	Scientific reports 2016-02, Vol.6 (1), p.20509-20509, Article 20509
Hauptverfasser:	Quinn, Phyllis M., Dunne, David W., Moore, Shona C., Pleass, Richard J.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/256 631/45/612/1221 82/1 alpha 1-Antitrypsin - metabolism Helminthiasis - immunology Humanities and Social Sciences Humans Immunoglobulin E - chemistry Immunoglobulin E - metabolism multidisciplinary Protein Isoforms - metabolism Proteolysis Receptors, IgE - metabolism Science
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