Differential clinical effects of different mutation subtypes in CALR-mutant myeloproliferative neoplasms

A quarter of patients with essential thrombocythemia or primary myelofibrosis carry a driver mutation of CALR , the calreticulin gene. A 52-bp deletion (type 1) and a 5-bp insertion (type 2 mutation) are the most frequent variants. These indels might differentially impair the calcium binding activit...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Leukemia 2016-02, Vol.30 (2), p.431-438
Hauptverfasser:	Pietra, D, Rumi, E, Ferretti, V V, Buduo, C A Di, Milanesi, C, Cavalloni, C, Sant'Antonio, E, Abbonante, V, Moccia, F, Casetti, I C, Bellini, M, Renna, M C, Roncoroni, E, Fugazza, E, Astori, C, Boveri, E, Rosti, V, Barosi, G, Balduini, A, Cazzola, M
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/737 631/67/68 631/80/86/1999 692/308/575 692/699/1541 692/699/1541/1990/2331 Adolescent Adult Aged Aged, 80 and over Calcium - metabolism Calreticulin - genetics Cancer Research Cells, Cultured Critical Care Medicine Development and progression Exons Female Gene mutations Genetic aspects Health aspects Hematology Humans Intensive Internal Medicine Isoelectric Point Lectins Male Medicine Medicine & Public Health Megakaryocytes - metabolism Middle Aged Mutation Myeloproliferative disorders Oncology Original original-article Primary Myelofibrosis - genetics Primary Myelofibrosis - metabolism Thrombocythemia, Essential - genetics Thrombocythemia, Essential - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!