The spleen contributes to stroke induced neurodegeneration through interferon gamma signaling
Delayed neuronal death associated with stroke has been increasingly linked to the immune response to the injury. Splenectomy prior to middle cerebral artery occlusion (MCAO) is neuroprotective and significantly reduces neuroinflammation. The present study investigated whether splenic signaling occur...
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| Veröffentlicht in: | Metabolic brain disease 2012-06, Vol.27 (2), p.131-141 |
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| creator | Seifert, Hilary A. Leonardo, Christopher C. Hall, Aaron A. Rowe, Derrick D. Collier, Lisa A. Benkovic, Stanley A. Willing, Alison E. Pennypacker, Keith R. |
| description | Delayed neuronal death associated with stroke has been increasingly linked to the immune response to the injury. Splenectomy prior to middle cerebral artery occlusion (MCAO) is neuroprotective and significantly reduces neuroinflammation. The present study investigated whether splenic signaling occurs through interferon gamma (IFNγ). IFNγ was elevated early in spleens but later in the brains of rats following MCAO. Splenectomy decreased the amount of IFNγ in the infarct post-MCAO. Systemic administration of recombinant IFNγ abolished the protective effects of splenectomy with a concurrent increase in INFγ expression in the brain. These results suggest a role for spleen-derived IFNγ in stroke pathology. |
| doi_str_mv | 10.1007/s11011-012-9283-0 |
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Splenectomy prior to middle cerebral artery occlusion (MCAO) is neuroprotective and significantly reduces neuroinflammation. The present study investigated whether splenic signaling occurs through interferon gamma (IFNγ). IFNγ was elevated early in spleens but later in the brains of rats following MCAO. Splenectomy decreased the amount of IFNγ in the infarct post-MCAO. Systemic administration of recombinant IFNγ abolished the protective effects of splenectomy with a concurrent increase in INFγ expression in the brain. These results suggest a role for spleen-derived IFNγ in stroke pathology.</description><identifier>ISSN: 0885-7490</identifier><identifier>EISSN: 1573-7365</identifier><identifier>DOI: 10.1007/s11011-012-9283-0</identifier><identifier>PMID: 22354752</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Animals ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Brain ; Brain Ischemia - pathology ; Brain Ischemia - physiopathology ; Cell Hypoxia ; Cells, Cultured ; Cerebral blood flow ; Female ; Fluoresceins ; Fluorescent Dyes ; gamma -Interferon ; Immune response ; Immunohistochemistry ; Infarction, Middle Cerebral Artery - pathology ; Inflammation ; Injuries ; Interferon-gamma - pharmacology ; Interferon-gamma - physiology ; Ischemia ; Laser-Doppler Flowmetry ; Ligation ; Male ; Metabolic Diseases ; Metabolic disorders ; Middle Cerebral Artery - physiology ; Nerve Degeneration - physiopathology ; Neurodegeneration ; Neuroglia - metabolism ; Neurology ; Neurons - drug effects ; Neurons - metabolism ; Neuroprotection ; Neurosciences ; Oligodendroglia - metabolism ; Oncology ; Organic Chemicals ; Original Paper ; Pregnancy ; Rats ; Rats, Sprague-Dawley ; Recombinant Proteins - pharmacology ; Signal Transduction - physiology ; Spleen ; Spleen - metabolism ; Spleen - physiopathology ; Splenectomy ; Stroke ; Stroke - physiopathology</subject><ispartof>Metabolic brain disease, 2012-06, Vol.27 (2), p.131-141</ispartof><rights>Springer Science+Business Media, LLC 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c569t-d2538d3d1ba9dae472443ee50094eff671b7dcd174daec2ba002570aeebf93c63</citedby><cites>FETCH-LOGICAL-c569t-d2538d3d1ba9dae472443ee50094eff671b7dcd174daec2ba002570aeebf93c63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11011-012-9283-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11011-012-9283-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22354752$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Seifert, Hilary A.</creatorcontrib><creatorcontrib>Leonardo, Christopher C.</creatorcontrib><creatorcontrib>Hall, Aaron A.</creatorcontrib><creatorcontrib>Rowe, Derrick D.</creatorcontrib><creatorcontrib>Collier, Lisa A.</creatorcontrib><creatorcontrib>Benkovic, Stanley A.</creatorcontrib><creatorcontrib>Willing, Alison E.</creatorcontrib><creatorcontrib>Pennypacker, Keith R.</creatorcontrib><title>The spleen contributes to stroke induced neurodegeneration through interferon gamma signaling</title><title>Metabolic brain disease</title><addtitle>Metab Brain Dis</addtitle><addtitle>Metab Brain Dis</addtitle><description>Delayed neuronal death associated with stroke has been increasingly linked to the immune response to the injury. Splenectomy prior to middle cerebral artery occlusion (MCAO) is neuroprotective and significantly reduces neuroinflammation. The present study investigated whether splenic signaling occurs through interferon gamma (IFNγ). IFNγ was elevated early in spleens but later in the brains of rats following MCAO. Splenectomy decreased the amount of IFNγ in the infarct post-MCAO. Systemic administration of recombinant IFNγ abolished the protective effects of splenectomy with a concurrent increase in INFγ expression in the brain. These results suggest a role for spleen-derived IFNγ in stroke pathology.</description><subject>Animals</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain</subject><subject>Brain Ischemia - pathology</subject><subject>Brain Ischemia - physiopathology</subject><subject>Cell Hypoxia</subject><subject>Cells, Cultured</subject><subject>Cerebral blood flow</subject><subject>Female</subject><subject>Fluoresceins</subject><subject>Fluorescent Dyes</subject><subject>gamma -Interferon</subject><subject>Immune response</subject><subject>Immunohistochemistry</subject><subject>Infarction, Middle Cerebral Artery - pathology</subject><subject>Inflammation</subject><subject>Injuries</subject><subject>Interferon-gamma - pharmacology</subject><subject>Interferon-gamma - physiology</subject><subject>Ischemia</subject><subject>Laser-Doppler Flowmetry</subject><subject>Ligation</subject><subject>Male</subject><subject>Metabolic Diseases</subject><subject>Metabolic disorders</subject><subject>Middle Cerebral Artery - physiology</subject><subject>Nerve Degeneration - physiopathology</subject><subject>Neurodegeneration</subject><subject>Neuroglia - metabolism</subject><subject>Neurology</subject><subject>Neurons - drug effects</subject><subject>Neurons - metabolism</subject><subject>Neuroprotection</subject><subject>Neurosciences</subject><subject>Oligodendroglia - metabolism</subject><subject>Oncology</subject><subject>Organic Chemicals</subject><subject>Original Paper</subject><subject>Pregnancy</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Recombinant Proteins - pharmacology</subject><subject>Signal Transduction - physiology</subject><subject>Spleen</subject><subject>Spleen - metabolism</subject><subject>Spleen - physiopathology</subject><subject>Splenectomy</subject><subject>Stroke</subject><subject>Stroke - physiopathology</subject><issn>0885-7490</issn><issn>1573-7365</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkU-LFDEQxYMo7rj6AbxIgxcvrZV_k8lFkEVXYcHLepSQTqp7snYnY5IW_PZmd9ZlFQRPgapfvVS9R8hzCq8pgHpTKAVKe6Cs12zHe3hANlQq3iu-lQ_JBnY72Suh4YQ8KeUKALik-jE5YYxLoSTbkK-Xe-zKYUaMnUux5jCsFUtXU1dqTt-wC9GvDn0Xcc3J44QRs60hxa7uc1qnfSMq5hFzK012WWxXwhTtHOL0lDwa7Vzw2e17Sr58eH959rG_-Hz-6ezdRe_kVtfeM8l3nns6WO0tCsWE4IgSQAscx62ig_LOUyVa17HBAjCpwCIOo-Zuy0_J26PuYR0W9A7bIXY2hxwWm3-aZIP5sxPD3kzphxGK62ZWE3h1K5DT9xVLNUsoDufZRkxrMc1npRXotuh_oFRy1W5o6Mu_0Ku05mbNDcWFaqK8UfRIuZxKyTje7U3BXOdsjjmblrO5ztlAm3lx_-C7id_BNoAdgdJaccJ8_-t_qf4CgY21cg</recordid><startdate>20120601</startdate><enddate>20120601</enddate><creator>Seifert, Hilary A.</creator><creator>Leonardo, Christopher C.</creator><creator>Hall, Aaron A.</creator><creator>Rowe, Derrick D.</creator><creator>Collier, Lisa A.</creator><creator>Benkovic, Stanley A.</creator><creator>Willing, Alison E.</creator><creator>Pennypacker, Keith R.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>20120601</creationdate><title>The spleen contributes to stroke induced neurodegeneration through interferon gamma signaling</title><author>Seifert, Hilary A. ; Leonardo, Christopher C. ; Hall, Aaron A. ; Rowe, Derrick D. ; Collier, Lisa A. ; Benkovic, Stanley A. ; Willing, Alison E. ; Pennypacker, Keith R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c569t-d2538d3d1ba9dae472443ee50094eff671b7dcd174daec2ba002570aeebf93c63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brain</topic><topic>Brain Ischemia - 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Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Metabolic brain disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Seifert, Hilary A.</au><au>Leonardo, Christopher C.</au><au>Hall, Aaron A.</au><au>Rowe, Derrick D.</au><au>Collier, Lisa A.</au><au>Benkovic, Stanley A.</au><au>Willing, Alison E.</au><au>Pennypacker, Keith R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The spleen contributes to stroke induced neurodegeneration through interferon gamma signaling</atitle><jtitle>Metabolic brain disease</jtitle><stitle>Metab Brain Dis</stitle><addtitle>Metab Brain Dis</addtitle><date>2012-06-01</date><risdate>2012</risdate><volume>27</volume><issue>2</issue><spage>131</spage><epage>141</epage><pages>131-141</pages><issn>0885-7490</issn><eissn>1573-7365</eissn><abstract>Delayed neuronal death associated with stroke has been increasingly linked to the immune response to the injury. Splenectomy prior to middle cerebral artery occlusion (MCAO) is neuroprotective and significantly reduces neuroinflammation. The present study investigated whether splenic signaling occurs through interferon gamma (IFNγ). IFNγ was elevated early in spleens but later in the brains of rats following MCAO. Splenectomy decreased the amount of IFNγ in the infarct post-MCAO. Systemic administration of recombinant IFNγ abolished the protective effects of splenectomy with a concurrent increase in INFγ expression in the brain. These results suggest a role for spleen-derived IFNγ in stroke pathology.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>22354752</pmid><doi>10.1007/s11011-012-9283-0</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Biochemistry Biomedical and Life Sciences Biomedicine Brain Brain Ischemia - pathology Brain Ischemia - physiopathology Cell Hypoxia Cells, Cultured Cerebral blood flow Female Fluoresceins Fluorescent Dyes gamma -Interferon Immune response Immunohistochemistry Infarction, Middle Cerebral Artery - pathology Inflammation Injuries Interferon-gamma - pharmacology Interferon-gamma - physiology Ischemia Laser-Doppler Flowmetry Ligation Male Metabolic Diseases Metabolic disorders Middle Cerebral Artery - physiology Nerve Degeneration - physiopathology Neurodegeneration Neuroglia - metabolism Neurology Neurons - drug effects Neurons - metabolism Neuroprotection Neurosciences Oligodendroglia - metabolism Oncology Organic Chemicals Original Paper Pregnancy Rats Rats, Sprague-Dawley Recombinant Proteins - pharmacology Signal Transduction - physiology Spleen Spleen - metabolism Spleen - physiopathology Splenectomy Stroke Stroke - physiopathology |
| title | The spleen contributes to stroke induced neurodegeneration through interferon gamma signaling |
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