Modulation of EZH2 Expression by MEK-ERK or PI3K-AKT Signaling in Lung Cancer Is Dictated by Different KRAS Oncogene Mutations

EZH2 overexpression promotes cancer by increasing histone methylation to silence tumor suppressor genes, but how EZH2 levels become elevated in cancer is not understood. In this study, we investigated the mechanisms by which EZH2 expression is regulated in non-small cell lung carcinoma cells by onco...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2016-02, Vol.76 (3), p.675-685
Hauptverfasser:	Riquelme, Erick, Behrens, Carmen, Lin, Heather Y, Simon, George, Papadimitrakopoulou, Vassiliki, Izzo, Julie, Moran, Cesar, Kalhor, Neda, Lee, J Jack, Minna, John D, Wistuba, Ignacio I
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - genetics Adenocarcinoma - metabolism Adenocarcinoma of Lung Animals Cell Line, Tumor Enhancer of Zeste Homolog 2 Protein Female Genes, ras Heterografts Humans Lung Neoplasms - genetics Lung Neoplasms - metabolism MAP Kinase Signaling System Mice Mice, Nude Mutation Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Polycomb Repressive Complex 2 - biosynthesis Polycomb Repressive Complex 2 - genetics Polycomb Repressive Complex 2 - metabolism ras Proteins - genetics ras Proteins - metabolism Transfection
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