Effect of low-dose selenium on thyroid autoimmunity and thyroid function in UK pregnant women with mild-to-moderate iodine deficiency
PURPOSE: Selenium is an essential trace mineral and a component of selenoproteins that are involved in the production of thyroid hormones and in regulating the immune response. We aimed to explore the effect of low-dose selenium supplementation on thyroid peroxidase antibody (TPO-Ab) concentration a...
Gespeichert in:
| Veröffentlicht in: | European journal of nutrition 2016-02, Vol.55 (1), p.55-61 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 61 |
|---|---|
| container_issue | 1 |
| container_start_page | 55 |
| container_title | European journal of nutrition |
| container_volume | 55 |
| creator | Mao, Jinyuan Pop, Victor J Bath, Sarah C Vader, Huib L Redman, Christopher W. G Rayman, Margaret P |
| description | PURPOSE: Selenium is an essential trace mineral and a component of selenoproteins that are involved in the production of thyroid hormones and in regulating the immune response. We aimed to explore the effect of low-dose selenium supplementation on thyroid peroxidase antibody (TPO-Ab) concentration and thyroid function in pregnant women from a mild-to-moderate iodine-deficient population. METHODS: Samples and data were from a secondary analysis of Selenium in PRegnancy INTervention (SPRINT), a double-blind, randomized, placebo-controlled study that recruited 230 women with singleton pregnancies from a UK antenatal clinic at 12 weeks of gestation. Women were randomized to receive 60 µg/day selenium or placebo until delivery. Serum thyroid peroxidase antibodies (TPO-Ab), thyrotropin (TSH) and free thyroxine (FT4) were measured at 12, 20 and 35 weeks and thyroglobulin antibodies (Tg-Ab) at 12 weeks. RESULTS: 93.5 % of participants completed the study. Se supplementation had no more effect than placebo in decreasing TPO-Ab concentration or the prevalence of TPO-Ab positivity during the course of pregnancy. In women who were either TPO-Ab or Tg-Ab negative at baseline (Thy-Ab⁻ᵛᵉ), TSH increased and FT4 decreased significantly throughout gestation (P |
| doi_str_mv | 10.1007/s00394-014-0822-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4737786</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3940351431</sourcerecordid><originalsourceid>FETCH-LOGICAL-c630t-1f815ed7aa5b2a9c1e8e41343dc3204a40713ec6f9a52e2a17b252a0ab7616223</originalsourceid><addsrcrecordid>eNqFks2OFCEUhYnROGPrA7hREjduSvmpgqqNyWQy_sRJXGivCQ2XbiZV0AJlpx_A95ZJjZ3RhS4IJOc7hws5CD2n5A0lRL7NhPChbQitq2esGR6gc9py0QhGu4enM5Fn6EnON4QQxgV9jM5Y17GWM3mOfl45B6bg6PAYD42NGXCGEYKfJxwDLrtjit5iPZfop2kOvhyxDvYkuDmY4ivpA15_xvsE26BDwYc4QcAHX3Z48qNtSmymaCHpAthH6wNgC84bD8Ecn6JHTo8Znt3tK7R-f_Xt8mNz_eXDp8uL68YITkpDXU87sFLrbsP0YCj00FLecms4I61uiaQcjHCD7hgwTeWGdUwTvZGCCsb4Cr1bcvfzZgJrIJSkR7VPftLpqKL26k8l-J3axh-qlVzKXtSA13cBKX6fIRc1-WxgHHWAOGdFe8LJIKjs_49KyXsmZUsq-uov9CbOKdSfqJSggxxYHWCF6EKZFHNO4E5zU6Ju-6CWPqjaB3XbBzVUz4v7Dz45fhegAmwBcpXCFtK9q_-R-nIxOR2V3iaf1forI1TUhvWy7zv-C6gRy4Y</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1761979247</pqid></control><display><type>article</type><title>Effect of low-dose selenium on thyroid autoimmunity and thyroid function in UK pregnant women with mild-to-moderate iodine deficiency</title><source>MEDLINE</source><source>Springer Online Journals</source><creator>Mao, Jinyuan ; Pop, Victor J ; Bath, Sarah C ; Vader, Huib L ; Redman, Christopher W. G ; Rayman, Margaret P</creator><creatorcontrib>Mao, Jinyuan ; Pop, Victor J ; Bath, Sarah C ; Vader, Huib L ; Redman, Christopher W. G ; Rayman, Margaret P</creatorcontrib><description>PURPOSE: Selenium is an essential trace mineral and a component of selenoproteins that are involved in the production of thyroid hormones and in regulating the immune response. We aimed to explore the effect of low-dose selenium supplementation on thyroid peroxidase antibody (TPO-Ab) concentration and thyroid function in pregnant women from a mild-to-moderate iodine-deficient population. METHODS: Samples and data were from a secondary analysis of Selenium in PRegnancy INTervention (SPRINT), a double-blind, randomized, placebo-controlled study that recruited 230 women with singleton pregnancies from a UK antenatal clinic at 12 weeks of gestation. Women were randomized to receive 60 µg/day selenium or placebo until delivery. Serum thyroid peroxidase antibodies (TPO-Ab), thyrotropin (TSH) and free thyroxine (FT4) were measured at 12, 20 and 35 weeks and thyroglobulin antibodies (Tg-Ab) at 12 weeks. RESULTS: 93.5 % of participants completed the study. Se supplementation had no more effect than placebo in decreasing TPO-Ab concentration or the prevalence of TPO-Ab positivity during the course of pregnancy. In women who were either TPO-Ab or Tg-Ab negative at baseline (Thy-Ab⁻ᵛᵉ), TSH increased and FT4 decreased significantly throughout gestation (P < 0.001), with no difference between treatment groups. In women who were Thy-Ab⁺ᵛᵉ at baseline, TSH tended to decrease and was lower than placebo at 35 weeks (P = 0.050). FT4 fell more on Se than placebo supplementation and was significantly lower at 35 weeks (P = 0.029). CONCLUSIONS: Low-dose selenium supplementation in pregnant women with mild-to-moderate deficiency had no effect on TPO-Ab concentration, but tended to change thyroid function in Thy-Ab⁺ᵛᵉ women.</description><identifier>ISSN: 1436-6207</identifier><identifier>EISSN: 1436-6215</identifier><identifier>DOI: 10.1007/s00394-014-0822-9</identifier><identifier>PMID: 25524327</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>antibodies ; Autoantibodies - blood ; autoimmunity ; blood serum ; Body Mass Index ; Chemistry ; Chemistry and Materials Science ; Dietary Supplements ; Dose-Response Relationship, Drug ; Double-Blind Method ; feed supplements ; Female ; Humans ; immune response ; iodide peroxidase ; Iodine - blood ; Iodine - deficiency ; Nutrition ; Original Contribution ; placebos ; Pregnancy ; pregnant women ; selenium ; Selenium - administration & dosage ; Selenium - blood ; selenoproteins ; thyroglobulin ; thyroid function ; Thyroid Gland - drug effects ; Thyroid Gland - immunology ; thyroid hormones ; thyrotropin ; Thyrotropin - blood ; thyroxine ; Thyroxine - blood ; United Kingdom</subject><ispartof>European journal of nutrition, 2016-02, Vol.55 (1), p.55-61</ispartof><rights>The Author(s) 2014</rights><rights>Springer-Verlag Berlin Heidelberg 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c630t-1f815ed7aa5b2a9c1e8e41343dc3204a40713ec6f9a52e2a17b252a0ab7616223</citedby><cites>FETCH-LOGICAL-c630t-1f815ed7aa5b2a9c1e8e41343dc3204a40713ec6f9a52e2a17b252a0ab7616223</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00394-014-0822-9$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00394-014-0822-9$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25524327$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mao, Jinyuan</creatorcontrib><creatorcontrib>Pop, Victor J</creatorcontrib><creatorcontrib>Bath, Sarah C</creatorcontrib><creatorcontrib>Vader, Huib L</creatorcontrib><creatorcontrib>Redman, Christopher W. G</creatorcontrib><creatorcontrib>Rayman, Margaret P</creatorcontrib><title>Effect of low-dose selenium on thyroid autoimmunity and thyroid function in UK pregnant women with mild-to-moderate iodine deficiency</title><title>European journal of nutrition</title><addtitle>Eur J Nutr</addtitle><addtitle>Eur J Nutr</addtitle><description>PURPOSE: Selenium is an essential trace mineral and a component of selenoproteins that are involved in the production of thyroid hormones and in regulating the immune response. We aimed to explore the effect of low-dose selenium supplementation on thyroid peroxidase antibody (TPO-Ab) concentration and thyroid function in pregnant women from a mild-to-moderate iodine-deficient population. METHODS: Samples and data were from a secondary analysis of Selenium in PRegnancy INTervention (SPRINT), a double-blind, randomized, placebo-controlled study that recruited 230 women with singleton pregnancies from a UK antenatal clinic at 12 weeks of gestation. Women were randomized to receive 60 µg/day selenium or placebo until delivery. Serum thyroid peroxidase antibodies (TPO-Ab), thyrotropin (TSH) and free thyroxine (FT4) were measured at 12, 20 and 35 weeks and thyroglobulin antibodies (Tg-Ab) at 12 weeks. RESULTS: 93.5 % of participants completed the study. Se supplementation had no more effect than placebo in decreasing TPO-Ab concentration or the prevalence of TPO-Ab positivity during the course of pregnancy. In women who were either TPO-Ab or Tg-Ab negative at baseline (Thy-Ab⁻ᵛᵉ), TSH increased and FT4 decreased significantly throughout gestation (P < 0.001), with no difference between treatment groups. In women who were Thy-Ab⁺ᵛᵉ at baseline, TSH tended to decrease and was lower than placebo at 35 weeks (P = 0.050). FT4 fell more on Se than placebo supplementation and was significantly lower at 35 weeks (P = 0.029). CONCLUSIONS: Low-dose selenium supplementation in pregnant women with mild-to-moderate deficiency had no effect on TPO-Ab concentration, but tended to change thyroid function in Thy-Ab⁺ᵛᵉ women.</description><subject>antibodies</subject><subject>Autoantibodies - blood</subject><subject>autoimmunity</subject><subject>blood serum</subject><subject>Body Mass Index</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Dietary Supplements</subject><subject>Dose-Response Relationship, Drug</subject><subject>Double-Blind Method</subject><subject>feed supplements</subject><subject>Female</subject><subject>Humans</subject><subject>immune response</subject><subject>iodide peroxidase</subject><subject>Iodine - blood</subject><subject>Iodine - deficiency</subject><subject>Nutrition</subject><subject>Original Contribution</subject><subject>placebos</subject><subject>Pregnancy</subject><subject>pregnant women</subject><subject>selenium</subject><subject>Selenium - administration & dosage</subject><subject>Selenium - blood</subject><subject>selenoproteins</subject><subject>thyroglobulin</subject><subject>thyroid function</subject><subject>Thyroid Gland - drug effects</subject><subject>Thyroid Gland - immunology</subject><subject>thyroid hormones</subject><subject>thyrotropin</subject><subject>Thyrotropin - blood</subject><subject>thyroxine</subject><subject>Thyroxine - blood</subject><subject>United Kingdom</subject><issn>1436-6207</issn><issn>1436-6215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFks2OFCEUhYnROGPrA7hREjduSvmpgqqNyWQy_sRJXGivCQ2XbiZV0AJlpx_A95ZJjZ3RhS4IJOc7hws5CD2n5A0lRL7NhPChbQitq2esGR6gc9py0QhGu4enM5Fn6EnON4QQxgV9jM5Y17GWM3mOfl45B6bg6PAYD42NGXCGEYKfJxwDLrtjit5iPZfop2kOvhyxDvYkuDmY4ivpA15_xvsE26BDwYc4QcAHX3Z48qNtSmymaCHpAthH6wNgC84bD8Ecn6JHTo8Znt3tK7R-f_Xt8mNz_eXDp8uL68YITkpDXU87sFLrbsP0YCj00FLecms4I61uiaQcjHCD7hgwTeWGdUwTvZGCCsb4Cr1bcvfzZgJrIJSkR7VPftLpqKL26k8l-J3axh-qlVzKXtSA13cBKX6fIRc1-WxgHHWAOGdFe8LJIKjs_49KyXsmZUsq-uov9CbOKdSfqJSggxxYHWCF6EKZFHNO4E5zU6Ju-6CWPqjaB3XbBzVUz4v7Dz45fhegAmwBcpXCFtK9q_-R-nIxOR2V3iaf1forI1TUhvWy7zv-C6gRy4Y</recordid><startdate>20160201</startdate><enddate>20160201</enddate><creator>Mao, Jinyuan</creator><creator>Pop, Victor J</creator><creator>Bath, Sarah C</creator><creator>Vader, Huib L</creator><creator>Redman, Christopher W. G</creator><creator>Rayman, Margaret P</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RQ</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7T5</scope><scope>H94</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope></search><sort><creationdate>20160201</creationdate><title>Effect of low-dose selenium on thyroid autoimmunity and thyroid function in UK pregnant women with mild-to-moderate iodine deficiency</title><author>Mao, Jinyuan ; Pop, Victor J ; Bath, Sarah C ; Vader, Huib L ; Redman, Christopher W. G ; Rayman, Margaret P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c630t-1f815ed7aa5b2a9c1e8e41343dc3204a40713ec6f9a52e2a17b252a0ab7616223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>antibodies</topic><topic>Autoantibodies - blood</topic><topic>autoimmunity</topic><topic>blood serum</topic><topic>Body Mass Index</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Dietary Supplements</topic><topic>Dose-Response Relationship, Drug</topic><topic>Double-Blind Method</topic><topic>feed supplements</topic><topic>Female</topic><topic>Humans</topic><topic>immune response</topic><topic>iodide peroxidase</topic><topic>Iodine - blood</topic><topic>Iodine - deficiency</topic><topic>Nutrition</topic><topic>Original Contribution</topic><topic>placebos</topic><topic>Pregnancy</topic><topic>pregnant women</topic><topic>selenium</topic><topic>Selenium - administration & dosage</topic><topic>Selenium - blood</topic><topic>selenoproteins</topic><topic>thyroglobulin</topic><topic>thyroid function</topic><topic>Thyroid Gland - drug effects</topic><topic>Thyroid Gland - immunology</topic><topic>thyroid hormones</topic><topic>thyrotropin</topic><topic>Thyrotropin - blood</topic><topic>thyroxine</topic><topic>Thyroxine - blood</topic><topic>United Kingdom</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mao, Jinyuan</creatorcontrib><creatorcontrib>Pop, Victor J</creatorcontrib><creatorcontrib>Bath, Sarah C</creatorcontrib><creatorcontrib>Vader, Huib L</creatorcontrib><creatorcontrib>Redman, Christopher W. G</creatorcontrib><creatorcontrib>Rayman, Margaret P</creatorcontrib><collection>AGRIS</collection><collection>SpringerOpen</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Career & Technical Education Database</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mao, Jinyuan</au><au>Pop, Victor J</au><au>Bath, Sarah C</au><au>Vader, Huib L</au><au>Redman, Christopher W. G</au><au>Rayman, Margaret P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of low-dose selenium on thyroid autoimmunity and thyroid function in UK pregnant women with mild-to-moderate iodine deficiency</atitle><jtitle>European journal of nutrition</jtitle><stitle>Eur J Nutr</stitle><addtitle>Eur J Nutr</addtitle><date>2016-02-01</date><risdate>2016</risdate><volume>55</volume><issue>1</issue><spage>55</spage><epage>61</epage><pages>55-61</pages><issn>1436-6207</issn><eissn>1436-6215</eissn><abstract>PURPOSE: Selenium is an essential trace mineral and a component of selenoproteins that are involved in the production of thyroid hormones and in regulating the immune response. We aimed to explore the effect of low-dose selenium supplementation on thyroid peroxidase antibody (TPO-Ab) concentration and thyroid function in pregnant women from a mild-to-moderate iodine-deficient population. METHODS: Samples and data were from a secondary analysis of Selenium in PRegnancy INTervention (SPRINT), a double-blind, randomized, placebo-controlled study that recruited 230 women with singleton pregnancies from a UK antenatal clinic at 12 weeks of gestation. Women were randomized to receive 60 µg/day selenium or placebo until delivery. Serum thyroid peroxidase antibodies (TPO-Ab), thyrotropin (TSH) and free thyroxine (FT4) were measured at 12, 20 and 35 weeks and thyroglobulin antibodies (Tg-Ab) at 12 weeks. RESULTS: 93.5 % of participants completed the study. Se supplementation had no more effect than placebo in decreasing TPO-Ab concentration or the prevalence of TPO-Ab positivity during the course of pregnancy. In women who were either TPO-Ab or Tg-Ab negative at baseline (Thy-Ab⁻ᵛᵉ), TSH increased and FT4 decreased significantly throughout gestation (P < 0.001), with no difference between treatment groups. In women who were Thy-Ab⁺ᵛᵉ at baseline, TSH tended to decrease and was lower than placebo at 35 weeks (P = 0.050). FT4 fell more on Se than placebo supplementation and was significantly lower at 35 weeks (P = 0.029). CONCLUSIONS: Low-dose selenium supplementation in pregnant women with mild-to-moderate deficiency had no effect on TPO-Ab concentration, but tended to change thyroid function in Thy-Ab⁺ᵛᵉ women.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>25524327</pmid><doi>10.1007/s00394-014-0822-9</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1436-6207 |
| ispartof | European journal of nutrition, 2016-02, Vol.55 (1), p.55-61 |
| issn | 1436-6207 1436-6215 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4737786 |
| source | MEDLINE; Springer Online Journals |
| subjects | antibodies Autoantibodies - blood autoimmunity blood serum Body Mass Index Chemistry Chemistry and Materials Science Dietary Supplements Dose-Response Relationship, Drug Double-Blind Method feed supplements Female Humans immune response iodide peroxidase Iodine - blood Iodine - deficiency Nutrition Original Contribution placebos Pregnancy pregnant women selenium Selenium - administration & dosage Selenium - blood selenoproteins thyroglobulin thyroid function Thyroid Gland - drug effects Thyroid Gland - immunology thyroid hormones thyrotropin Thyrotropin - blood thyroxine Thyroxine - blood United Kingdom |
| title | Effect of low-dose selenium on thyroid autoimmunity and thyroid function in UK pregnant women with mild-to-moderate iodine deficiency |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-14T14%3A26%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20low-dose%20selenium%20on%20thyroid%20autoimmunity%20and%20thyroid%20function%20in%20UK%20pregnant%20women%20with%20mild-to-moderate%20iodine%20deficiency&rft.jtitle=European%20journal%20of%20nutrition&rft.au=Mao,%20Jinyuan&rft.date=2016-02-01&rft.volume=55&rft.issue=1&rft.spage=55&rft.epage=61&rft.pages=55-61&rft.issn=1436-6207&rft.eissn=1436-6215&rft_id=info:doi/10.1007/s00394-014-0822-9&rft_dat=%3Cproquest_pubme%3E3940351431%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1761979247&rft_id=info:pmid/25524327&rfr_iscdi=true |