Maresin 1, a Proresolving Lipid Mediator, Mitigates Carbon Tetrachloride-Induced Liver Injury in Mice

Maresin 1 (MaR 1) was recently reported to have protective properties in several different animal models of acute inflammation by inhibiting inflammatory response. However, its function in acute liver injury is still unknown. To address this question, we induced liver injury in BALB/c mice with intr...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2016-01, Vol.2016 (2016), p.1-13
Hauptverfasser:	Deng, Meizhou, Zhang, Peng, Tao, Kaixiong, Xie, Gengchen, Wang, Di, Shi, Liang, Li, Wei, Wu, Ke, Zhao, Ende, Wang, Yaxin, Li, Ruidong, Yin, Yuping
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Transaminase - blood Animals Antioxidants - metabolism Aspartate Aminotransferases - blood Carbon Carbon Tetrachloride Cell Nucleus - drug effects Cell Nucleus - metabolism Chemicals Colleges & universities Cyclooxygenase 2 - metabolism Cytokines Cytokines - blood Docosahexaenoic Acids - administration & dosage Docosahexaenoic Acids - pharmacology Enzymes Fatty acids Glutathione - metabolism Hep G2 Cells Humans Inflammation Inflammation Mediators - metabolism Interleukins Kinases Laboratories Lipid peroxidation Lipids Liver Liver - drug effects Liver - pathology Liver diseases Male Mice, Inbred BALB C Mitogen-Activated Protein Kinases - metabolism NF-KappaB Inhibitor alpha - metabolism Nitric oxide Nitric Oxide Synthase Type II - metabolism Oxidative stress Oxidative Stress - drug effects Peroxidase - metabolism Phosphorylation Phosphorylation - drug effects Reactive Oxygen Species - metabolism Rodents Science Thiobarbituric Acid Reactive Substances - metabolism Transcription Factor RelA - metabolism
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