Developmental expression and cardiac transcriptional regulation of Myh7b, a third myosin heavy chain in the vertebrate heart

The mammalian heart expresses two myosin heavy chain (MYH) genes (Myh6 and Myh7), which are major components of the thick filaments of the sarcomere. We have determined that a third MYH, MYH7B, is also expressed in the myocardium. Developmental analysis shows Myh7b expression in cardiac and skeletal...

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Veröffentlicht in:	Cytoskeleton (Hoboken, N.J.) N.J.), 2012-05, Vol.69 (5), p.324-335
Hauptverfasser:	Warkman, Andrew S., Whitman, Samantha A., Miller, Melanie K., Garriock, Robert J., Schwach, Catherine M., Gregorio, Carol C., Krieg, Paul A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Amino Acid Sequence Animals Base Sequence Binding Sites Blotting, Western cardiac development Cardiomegaly - genetics Cardiomegaly - metabolism Cardiomegaly - pathology Cell Nucleus - metabolism Cells, Cultured Chick Embryo DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Gene Expression Regulation, Developmental Heart - embryology Heart - physiology Humans hypertrophy Immunoenzyme Techniques In Situ Hybridization Luciferases - metabolism Mice - embryology Molecular Sequence Data Muscle, Skeletal - cytology Muscle, Skeletal - metabolism Myocardium - cytology Myocardium - metabolism myosin heavy chain Myosin Heavy Chains - genetics Myosin Heavy Chains - metabolism promoter analysis Promoter Regions, Genetic - genetics Rats Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Sequence Homology, Amino Acid Sequence Homology, Nucleic Acid smooth muscle somites Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic Transcriptional Activation Xenopus laevis - embryology
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