Association of Decreased Expression of Serum miR-9 with Poor Prognosis of Oral Squamous Cell Carcinoma Patients
Dysregulation of miR-9 is a common feature of many types of cancers, including oral squamous cell carcinoma (OSCC). However, whether the expression level of serum miR-9 is changed in patients with OSCC remains unknown. Quantitative real-time polymerase chain reaction (qRT-PCR) was performed to exami...
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| Veröffentlicht in: | Medical science monitor 2016-01, Vol.22, p.289-294 |
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| creator | Sun, Legang Liu, Ling Fu, Honghai Wang, Qiuqin Shi, Yao |
| description | Dysregulation of miR-9 is a common feature of many types of cancers, including oral squamous cell carcinoma (OSCC). However, whether the expression level of serum miR-9 is changed in patients with OSCC remains unknown.
Quantitative real-time polymerase chain reaction (qRT-PCR) was performed to examine the expression level of serum miR-9 in OSCC patients, oral leukoplakia (OLK) patients, and healthy volunteers, then we evaluated the association between serum miR-9 expression level and clinical outcome of OSCC patients.
The expression level of serum miR-9 was significantly downregulated in patients with OSCC or OLK in comparison with healthy controls (P |
| doi_str_mv | 10.12659/MSM.895683 |
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Quantitative real-time polymerase chain reaction (qRT-PCR) was performed to examine the expression level of serum miR-9 in OSCC patients, oral leukoplakia (OLK) patients, and healthy volunteers, then we evaluated the association between serum miR-9 expression level and clinical outcome of OSCC patients.
The expression level of serum miR-9 was significantly downregulated in patients with OSCC or OLK in comparison with healthy controls (P<0.01). Serum miR-9 expression level was associated with various clinicopathological parameters, including T stage (P=0.013), lymph node metastasis (P=0.002), and TNM stage (P=0.007). In addition, the OSCC patients in the low serum miR-9 expression group had poorer overall survival rate (P=0.022) and disease-free survival rate (P=0.004) compared with those in the high serum miR-9 expression group. Multivariate analysis showed that serum miR-9 was an independent prognostic factor for OSCC.
Serum miR-9 was downregulated in patients with OSCC and patients with OLK. In addition, low serum miR-9 was correlated with poor prognosis of OSCC, indicating miR-9 might play a tumor suppressive role in OSCC and can serve as a promising biomarker for this deadly disease.</description><identifier>ISSN: 1643-3750</identifier><identifier>ISSN: 1234-1010</identifier><identifier>EISSN: 1643-3750</identifier><identifier>DOI: 10.12659/MSM.895683</identifier><identifier>PMID: 26813876</identifier><language>eng</language><publisher>United States: International Scientific Literature, Inc</publisher><subject>Aged ; Carcinoma, Squamous Cell - blood ; Carcinoma, Squamous Cell - genetics ; Carcinoma, Squamous Cell - pathology ; Clinical Research ; Disease-Free Survival ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Leukoplakia - genetics ; Male ; MicroRNAs - blood ; MicroRNAs - genetics ; Middle Aged ; Mouth Neoplasms - blood ; Mouth Neoplasms - genetics ; Mouth Neoplasms - pathology ; Multivariate Analysis ; Prognosis ; Risk Factors</subject><ispartof>Medical science monitor, 2016-01, Vol.22, p.289-294</ispartof><rights>Med Sci Monit, 2016 2016</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-917f99e3f7a61a3a0ec3f14932c5525ae5c6ecb08adc97d067f6ce7cc1de196d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4734672/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4734672/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27922,27923,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26813876$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sun, Legang</creatorcontrib><creatorcontrib>Liu, Ling</creatorcontrib><creatorcontrib>Fu, Honghai</creatorcontrib><creatorcontrib>Wang, Qiuqin</creatorcontrib><creatorcontrib>Shi, Yao</creatorcontrib><title>Association of Decreased Expression of Serum miR-9 with Poor Prognosis of Oral Squamous Cell Carcinoma Patients</title><title>Medical science monitor</title><addtitle>Med Sci Monit</addtitle><description>Dysregulation of miR-9 is a common feature of many types of cancers, including oral squamous cell carcinoma (OSCC). However, whether the expression level of serum miR-9 is changed in patients with OSCC remains unknown.
Quantitative real-time polymerase chain reaction (qRT-PCR) was performed to examine the expression level of serum miR-9 in OSCC patients, oral leukoplakia (OLK) patients, and healthy volunteers, then we evaluated the association between serum miR-9 expression level and clinical outcome of OSCC patients.
The expression level of serum miR-9 was significantly downregulated in patients with OSCC or OLK in comparison with healthy controls (P<0.01). Serum miR-9 expression level was associated with various clinicopathological parameters, including T stage (P=0.013), lymph node metastasis (P=0.002), and TNM stage (P=0.007). In addition, the OSCC patients in the low serum miR-9 expression group had poorer overall survival rate (P=0.022) and disease-free survival rate (P=0.004) compared with those in the high serum miR-9 expression group. Multivariate analysis showed that serum miR-9 was an independent prognostic factor for OSCC.
Serum miR-9 was downregulated in patients with OSCC and patients with OLK. In addition, low serum miR-9 was correlated with poor prognosis of OSCC, indicating miR-9 might play a tumor suppressive role in OSCC and can serve as a promising biomarker for this deadly disease.</description><subject>Aged</subject><subject>Carcinoma, Squamous Cell - blood</subject><subject>Carcinoma, Squamous Cell - genetics</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Clinical Research</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Leukoplakia - genetics</subject><subject>Male</subject><subject>MicroRNAs - blood</subject><subject>MicroRNAs - genetics</subject><subject>Middle Aged</subject><subject>Mouth Neoplasms - blood</subject><subject>Mouth Neoplasms - genetics</subject><subject>Mouth Neoplasms - pathology</subject><subject>Multivariate Analysis</subject><subject>Prognosis</subject><subject>Risk Factors</subject><issn>1643-3750</issn><issn>1234-1010</issn><issn>1643-3750</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkc1LAzEQxYMotlZP3iVHQVaTzW6yuQhSP6Glxeo5pNlZjXQ3Ndn147832ir1NMPMj_dmeAgdUnJKU57Ls_FsfFrInBdsC_Upz1jCRE62N_oe2gvhhZC04CTfRb2UF5QVgveRuwjBGatb6xrsKnwJxoMOUOKrj6WHENbzGfiuxrW9TyR-t-0znjrn8dS7p8YFG76RidcLPHvtdO26gIewWOCh9sY2rtZ4Gh2gacM-2qn0IsDBug7Q4_XVw_A2GU1u7oYXo8SwgraJpKKSElglNKeaaQKGVTSTLDV5nuYacsPBzEmhSyNFSbiouAFhDC2BSl6yATpf6S67eQ2lid7xPLX0ttb-Uzlt1f9NY5_Vk3tTmWAZF2kUOF4LePfaQWhVbYOJT-kG4n-KCk6JEExmET1Zoca7EDxUfzaUqJ-IVIxIrSKK9NHmZX_sbybsC7M6jq8</recordid><startdate>20160127</startdate><enddate>20160127</enddate><creator>Sun, Legang</creator><creator>Liu, Ling</creator><creator>Fu, Honghai</creator><creator>Wang, Qiuqin</creator><creator>Shi, Yao</creator><general>International Scientific Literature, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160127</creationdate><title>Association of Decreased Expression of Serum miR-9 with Poor Prognosis of Oral Squamous Cell Carcinoma Patients</title><author>Sun, Legang ; Liu, Ling ; Fu, Honghai ; Wang, Qiuqin ; Shi, Yao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-917f99e3f7a61a3a0ec3f14932c5525ae5c6ecb08adc97d067f6ce7cc1de196d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Carcinoma, Squamous Cell - blood</topic><topic>Carcinoma, Squamous Cell - genetics</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Clinical Research</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Leukoplakia - genetics</topic><topic>Male</topic><topic>MicroRNAs - blood</topic><topic>MicroRNAs - genetics</topic><topic>Middle Aged</topic><topic>Mouth Neoplasms - blood</topic><topic>Mouth Neoplasms - genetics</topic><topic>Mouth Neoplasms - pathology</topic><topic>Multivariate Analysis</topic><topic>Prognosis</topic><topic>Risk Factors</topic><toplevel>online_resources</toplevel><creatorcontrib>Sun, Legang</creatorcontrib><creatorcontrib>Liu, Ling</creatorcontrib><creatorcontrib>Fu, Honghai</creatorcontrib><creatorcontrib>Wang, Qiuqin</creatorcontrib><creatorcontrib>Shi, Yao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medical science monitor</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sun, Legang</au><au>Liu, Ling</au><au>Fu, Honghai</au><au>Wang, Qiuqin</au><au>Shi, Yao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of Decreased Expression of Serum miR-9 with Poor Prognosis of Oral Squamous Cell Carcinoma Patients</atitle><jtitle>Medical science monitor</jtitle><addtitle>Med Sci Monit</addtitle><date>2016-01-27</date><risdate>2016</risdate><volume>22</volume><spage>289</spage><epage>294</epage><pages>289-294</pages><issn>1643-3750</issn><issn>1234-1010</issn><eissn>1643-3750</eissn><abstract>Dysregulation of miR-9 is a common feature of many types of cancers, including oral squamous cell carcinoma (OSCC). However, whether the expression level of serum miR-9 is changed in patients with OSCC remains unknown.
Quantitative real-time polymerase chain reaction (qRT-PCR) was performed to examine the expression level of serum miR-9 in OSCC patients, oral leukoplakia (OLK) patients, and healthy volunteers, then we evaluated the association between serum miR-9 expression level and clinical outcome of OSCC patients.
The expression level of serum miR-9 was significantly downregulated in patients with OSCC or OLK in comparison with healthy controls (P<0.01). Serum miR-9 expression level was associated with various clinicopathological parameters, including T stage (P=0.013), lymph node metastasis (P=0.002), and TNM stage (P=0.007). In addition, the OSCC patients in the low serum miR-9 expression group had poorer overall survival rate (P=0.022) and disease-free survival rate (P=0.004) compared with those in the high serum miR-9 expression group. Multivariate analysis showed that serum miR-9 was an independent prognostic factor for OSCC.
Serum miR-9 was downregulated in patients with OSCC and patients with OLK. In addition, low serum miR-9 was correlated with poor prognosis of OSCC, indicating miR-9 might play a tumor suppressive role in OSCC and can serve as a promising biomarker for this deadly disease.</abstract><cop>United States</cop><pub>International Scientific Literature, Inc</pub><pmid>26813876</pmid><doi>10.12659/MSM.895683</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Carcinoma, Squamous Cell - blood Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology Clinical Research Disease-Free Survival Female Gene Expression Regulation, Neoplastic Humans Leukoplakia - genetics Male MicroRNAs - blood MicroRNAs - genetics Middle Aged Mouth Neoplasms - blood Mouth Neoplasms - genetics Mouth Neoplasms - pathology Multivariate Analysis Prognosis Risk Factors |
| title | Association of Decreased Expression of Serum miR-9 with Poor Prognosis of Oral Squamous Cell Carcinoma Patients |
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