RNA-seq analysis of impact of PNN on gene expression and alternative splicing in corneal epithelial cells

The specialized corneal epithelium requires differentiated properties, specific for its role at the anterior surface of the eye. Thus, tight maintenance of the differentiated qualities of the corneal epithelial is essential. Pinin (PNN) is an exon junction component (EJC) that has dramatic implicati...

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Veröffentlicht in:	Molecular vision 2016-01, Vol.22, p.40-60
Hauptverfasser:	Akin, Debra, Newman, Jeremy R B, McIntyre, Lauren M, Sugrue, Stephen P
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing - genetics Cell Adhesion Molecules - genetics Cell Adhesion Molecules - metabolism Cell Differentiation Cell Line Down-Regulation Epithelium, Corneal - cytology Epithelium, Corneal - metabolism Extracellular Matrix Proteins - genetics Extracellular Matrix Proteins - metabolism Fluorescent Antibody Technique, Indirect Gene Expression Regulation - physiology Humans Matrix Metalloproteinases - genetics Matrix Metalloproteinases - metabolism Nuclear Proteins - genetics Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Small Interfering - genetics Sequence Analysis, RNA - methods
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