Association between MMP-2 expression and prostate cancer: A meta-analysis
Matrix metalloproteinase-2 (MMP-2) is a member of the MMP family, which is associated with numerous types of cancer. Although it has been widely reported, the prognostic value of MMP-2 expression in prostate cancer (PCa) remains controversial. Thus, the present meta-analysis was conducted to investi...
Gespeichert in:
| Veröffentlicht in: | Biomedical reports 2016-02, Vol.4 (2), p.241-245 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 245 |
|---|---|
| container_issue | 2 |
| container_start_page | 241 |
| container_title | Biomedical reports |
| container_volume | 4 |
| creator | XIE, TIANCHENG DONG, BINBIN YAN, YANGYE HU, GUANGHUI XU, YUNFEI |
| description | Matrix metalloproteinase-2 (MMP-2) is a member of the MMP family, which is associated with numerous types of cancer. Although it has been widely reported, the prognostic value of MMP-2 expression in prostate cancer (PCa) remains controversial. Thus, the present meta-analysis was conducted to investigate the association and prognostic value of MMP-2 expression in PCa. PubMed, Cochrane Library and the China National Knowledge Infrastructure databases were searched for all the published case-control studies on the association between MMP-2 expression and PCa until July 2015. The odd ratios (ORs) and 95% confidence intervals (CIs) were used to estimate the association of MMP-2 expression and PCa. ORs and 95% CIs were applied to clarify this association. Several subgroup analyses were also conducted according to different indexes in the case group. In total, 8 studies including 675 patients were included in the final meta-analysis. The results of the meta-analysis showed that MMP-2 expression in the PCa group was significantly higher than that in the benign prostatic hyperplasia (BPH) group (95% CI, 0.06-0.15; Z=10.48; P |
| doi_str_mv | 10.3892/br.2015.553 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4734094</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A444866777</galeid><sourcerecordid>A444866777</sourcerecordid><originalsourceid>FETCH-LOGICAL-c504t-9d194b1133e35a30f9876772bb7de2609fd5a1a7c9183bc25db764f85b353e5c3</originalsourceid><addsrcrecordid>eNptkc9rFTEQx4Motjx78i4LXgTZ1_zcTTwIr6XaQoul6Dkk2dmaspusyT61_32ztL5aMXNISD7zzcx8EXpN8JpJRQ9tWlNMxFoI9gztU8xVrTinz3dnxvfQQc43uCzVYirkS7RHG6mY5M0-OtvkHJ03s4-hsjD_AgjVxcVlTSv4PSXIeXkwoaumFPNsZqicCQ7Sh2pTjTCb2gQz3GafX6EXvRkyHDzsK_Tt08nX49P6_Mvns-PNee0E5nOtOqK4JYQxYMIw3CvZNm1LrW07oA1WfScMMa1TRDLrqOhs2_BeCssEA-HYCn281522doTOQZiTGfSU_GjSrY7G66cvwX_X1_Gn5i3juAxkhd49CKT4Ywt51qPPDobBBIjbrImkTSOILCWu0Nt_0Ju4TaXhQimGFRUci0fq2gygfehj-dctonrDOZdN6a8t1Po_VIkORu9igN6X-ycJ7-8TXJl8TtDveiRYL-Zrm_Rivi7mF_rN32PZsX-sfqwyT8VO38W8Y46ualxikbkDgiOzHQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1930925405</pqid></control><display><type>article</type><title>Association between MMP-2 expression and prostate cancer: A meta-analysis</title><source>Spandidos Publications Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>XIE, TIANCHENG ; DONG, BINBIN ; YAN, YANGYE ; HU, GUANGHUI ; XU, YUNFEI</creator><creatorcontrib>XIE, TIANCHENG ; DONG, BINBIN ; YAN, YANGYE ; HU, GUANGHUI ; XU, YUNFEI</creatorcontrib><description>Matrix metalloproteinase-2 (MMP-2) is a member of the MMP family, which is associated with numerous types of cancer. Although it has been widely reported, the prognostic value of MMP-2 expression in prostate cancer (PCa) remains controversial. Thus, the present meta-analysis was conducted to investigate the association and prognostic value of MMP-2 expression in PCa. PubMed, Cochrane Library and the China National Knowledge Infrastructure databases were searched for all the published case-control studies on the association between MMP-2 expression and PCa until July 2015. The odd ratios (ORs) and 95% confidence intervals (CIs) were used to estimate the association of MMP-2 expression and PCa. ORs and 95% CIs were applied to clarify this association. Several subgroup analyses were also conducted according to different indexes in the case group. In total, 8 studies including 675 patients were included in the final meta-analysis. The results of the meta-analysis showed that MMP-2 expression in the PCa group was significantly higher than that in the benign prostatic hyperplasia (BPH) group (95% CI, 0.06-0.15; Z=10.48; P<0.00001). Furthermore, MMP-2 expression was significantly associated with Gleason Score (95% CI, 0.18-0.68; Z=3.09; P=0.002) and clinical stages (95% CI, 0.12-0.82; Z=2.36; P=0.02), and not significantly associated with Gleason score serum prostate specific antigen (95% CI, 0.30-1.66; Z=0.80; P=0.43). In conclusion, MMP-2 is overexpressed in PCa tissues compared with BPH. The expression of MMP-2 was significantly associated with the grade of PCa malignancy.</description><identifier>ISSN: 2049-9434</identifier><identifier>EISSN: 2049-9442</identifier><identifier>DOI: 10.3892/br.2015.553</identifier><identifier>PMID: 26893846</identifier><language>eng</language><publisher>England: D.A. Spandidos</publisher><subject>Antigens ; Benign ; benign prostatic hyperplasia ; Confidence intervals ; Gelatinase A ; Gene expression ; Genetic aspects ; Health aspects ; Hyperplasia ; Libraries ; Malignancy ; Matrix metalloproteinase ; matrix metalloproteinase-2 ; Medical prognosis ; Meta-analysis ; Metalloproteinase ; Metalloproteins ; Population ; Prostate cancer ; Quality ; Studies ; Survival analysis</subject><ispartof>Biomedical reports, 2016-02, Vol.4 (2), p.241-245</ispartof><rights>Copyright © 2016, Spandidos Publications</rights><rights>COPYRIGHT 2016 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2016</rights><rights>Copyright © 2016, Spandidos Publications 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c504t-9d194b1133e35a30f9876772bb7de2609fd5a1a7c9183bc25db764f85b353e5c3</citedby><cites>FETCH-LOGICAL-c504t-9d194b1133e35a30f9876772bb7de2609fd5a1a7c9183bc25db764f85b353e5c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4734094/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4734094/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,5571,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26893846$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>XIE, TIANCHENG</creatorcontrib><creatorcontrib>DONG, BINBIN</creatorcontrib><creatorcontrib>YAN, YANGYE</creatorcontrib><creatorcontrib>HU, GUANGHUI</creatorcontrib><creatorcontrib>XU, YUNFEI</creatorcontrib><title>Association between MMP-2 expression and prostate cancer: A meta-analysis</title><title>Biomedical reports</title><addtitle>Biomed Rep</addtitle><description>Matrix metalloproteinase-2 (MMP-2) is a member of the MMP family, which is associated with numerous types of cancer. Although it has been widely reported, the prognostic value of MMP-2 expression in prostate cancer (PCa) remains controversial. Thus, the present meta-analysis was conducted to investigate the association and prognostic value of MMP-2 expression in PCa. PubMed, Cochrane Library and the China National Knowledge Infrastructure databases were searched for all the published case-control studies on the association between MMP-2 expression and PCa until July 2015. The odd ratios (ORs) and 95% confidence intervals (CIs) were used to estimate the association of MMP-2 expression and PCa. ORs and 95% CIs were applied to clarify this association. Several subgroup analyses were also conducted according to different indexes in the case group. In total, 8 studies including 675 patients were included in the final meta-analysis. The results of the meta-analysis showed that MMP-2 expression in the PCa group was significantly higher than that in the benign prostatic hyperplasia (BPH) group (95% CI, 0.06-0.15; Z=10.48; P<0.00001). Furthermore, MMP-2 expression was significantly associated with Gleason Score (95% CI, 0.18-0.68; Z=3.09; P=0.002) and clinical stages (95% CI, 0.12-0.82; Z=2.36; P=0.02), and not significantly associated with Gleason score serum prostate specific antigen (95% CI, 0.30-1.66; Z=0.80; P=0.43). In conclusion, MMP-2 is overexpressed in PCa tissues compared with BPH. The expression of MMP-2 was significantly associated with the grade of PCa malignancy.</description><subject>Antigens</subject><subject>Benign</subject><subject>benign prostatic hyperplasia</subject><subject>Confidence intervals</subject><subject>Gelatinase A</subject><subject>Gene expression</subject><subject>Genetic aspects</subject><subject>Health aspects</subject><subject>Hyperplasia</subject><subject>Libraries</subject><subject>Malignancy</subject><subject>Matrix metalloproteinase</subject><subject>matrix metalloproteinase-2</subject><subject>Medical prognosis</subject><subject>Meta-analysis</subject><subject>Metalloproteinase</subject><subject>Metalloproteins</subject><subject>Population</subject><subject>Prostate cancer</subject><subject>Quality</subject><subject>Studies</subject><subject>Survival analysis</subject><issn>2049-9434</issn><issn>2049-9442</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptkc9rFTEQx4Motjx78i4LXgTZ1_zcTTwIr6XaQoul6Dkk2dmaspusyT61_32ztL5aMXNISD7zzcx8EXpN8JpJRQ9tWlNMxFoI9gztU8xVrTinz3dnxvfQQc43uCzVYirkS7RHG6mY5M0-OtvkHJ03s4-hsjD_AgjVxcVlTSv4PSXIeXkwoaumFPNsZqicCQ7Sh2pTjTCb2gQz3GafX6EXvRkyHDzsK_Tt08nX49P6_Mvns-PNee0E5nOtOqK4JYQxYMIw3CvZNm1LrW07oA1WfScMMa1TRDLrqOhs2_BeCssEA-HYCn281522doTOQZiTGfSU_GjSrY7G66cvwX_X1_Gn5i3juAxkhd49CKT4Ywt51qPPDobBBIjbrImkTSOILCWu0Nt_0Ju4TaXhQimGFRUci0fq2gygfehj-dctonrDOZdN6a8t1Po_VIkORu9igN6X-ycJ7-8TXJl8TtDveiRYL-Zrm_Rivi7mF_rN32PZsX-sfqwyT8VO38W8Y46ualxikbkDgiOzHQ</recordid><startdate>20160201</startdate><enddate>20160201</enddate><creator>XIE, TIANCHENG</creator><creator>DONG, BINBIN</creator><creator>YAN, YANGYE</creator><creator>HU, GUANGHUI</creator><creator>XU, YUNFEI</creator><general>D.A. Spandidos</general><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160201</creationdate><title>Association between MMP-2 expression and prostate cancer: A meta-analysis</title><author>XIE, TIANCHENG ; DONG, BINBIN ; YAN, YANGYE ; HU, GUANGHUI ; XU, YUNFEI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c504t-9d194b1133e35a30f9876772bb7de2609fd5a1a7c9183bc25db764f85b353e5c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Antigens</topic><topic>Benign</topic><topic>benign prostatic hyperplasia</topic><topic>Confidence intervals</topic><topic>Gelatinase A</topic><topic>Gene expression</topic><topic>Genetic aspects</topic><topic>Health aspects</topic><topic>Hyperplasia</topic><topic>Libraries</topic><topic>Malignancy</topic><topic>Matrix metalloproteinase</topic><topic>matrix metalloproteinase-2</topic><topic>Medical prognosis</topic><topic>Meta-analysis</topic><topic>Metalloproteinase</topic><topic>Metalloproteins</topic><topic>Population</topic><topic>Prostate cancer</topic><topic>Quality</topic><topic>Studies</topic><topic>Survival analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>XIE, TIANCHENG</creatorcontrib><creatorcontrib>DONG, BINBIN</creatorcontrib><creatorcontrib>YAN, YANGYE</creatorcontrib><creatorcontrib>HU, GUANGHUI</creatorcontrib><creatorcontrib>XU, YUNFEI</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Biomedical reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>XIE, TIANCHENG</au><au>DONG, BINBIN</au><au>YAN, YANGYE</au><au>HU, GUANGHUI</au><au>XU, YUNFEI</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between MMP-2 expression and prostate cancer: A meta-analysis</atitle><jtitle>Biomedical reports</jtitle><addtitle>Biomed Rep</addtitle><date>2016-02-01</date><risdate>2016</risdate><volume>4</volume><issue>2</issue><spage>241</spage><epage>245</epage><pages>241-245</pages><issn>2049-9434</issn><eissn>2049-9442</eissn><abstract>Matrix metalloproteinase-2 (MMP-2) is a member of the MMP family, which is associated with numerous types of cancer. Although it has been widely reported, the prognostic value of MMP-2 expression in prostate cancer (PCa) remains controversial. Thus, the present meta-analysis was conducted to investigate the association and prognostic value of MMP-2 expression in PCa. PubMed, Cochrane Library and the China National Knowledge Infrastructure databases were searched for all the published case-control studies on the association between MMP-2 expression and PCa until July 2015. The odd ratios (ORs) and 95% confidence intervals (CIs) were used to estimate the association of MMP-2 expression and PCa. ORs and 95% CIs were applied to clarify this association. Several subgroup analyses were also conducted according to different indexes in the case group. In total, 8 studies including 675 patients were included in the final meta-analysis. The results of the meta-analysis showed that MMP-2 expression in the PCa group was significantly higher than that in the benign prostatic hyperplasia (BPH) group (95% CI, 0.06-0.15; Z=10.48; P<0.00001). Furthermore, MMP-2 expression was significantly associated with Gleason Score (95% CI, 0.18-0.68; Z=3.09; P=0.002) and clinical stages (95% CI, 0.12-0.82; Z=2.36; P=0.02), and not significantly associated with Gleason score serum prostate specific antigen (95% CI, 0.30-1.66; Z=0.80; P=0.43). In conclusion, MMP-2 is overexpressed in PCa tissues compared with BPH. The expression of MMP-2 was significantly associated with the grade of PCa malignancy.</abstract><cop>England</cop><pub>D.A. Spandidos</pub><pmid>26893846</pmid><doi>10.3892/br.2015.553</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2049-9434 |
| ispartof | Biomedical reports, 2016-02, Vol.4 (2), p.241-245 |
| issn | 2049-9434 2049-9442 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4734094 |
| source | Spandidos Publications Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Antigens Benign benign prostatic hyperplasia Confidence intervals Gelatinase A Gene expression Genetic aspects Health aspects Hyperplasia Libraries Malignancy Matrix metalloproteinase matrix metalloproteinase-2 Medical prognosis Meta-analysis Metalloproteinase Metalloproteins Population Prostate cancer Quality Studies Survival analysis |
| title | Association between MMP-2 expression and prostate cancer: A meta-analysis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T02%3A22%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20between%20MMP-2%20expression%20and%20prostate%20cancer:%20A%20meta-analysis&rft.jtitle=Biomedical%20reports&rft.au=XIE,%20TIANCHENG&rft.date=2016-02-01&rft.volume=4&rft.issue=2&rft.spage=241&rft.epage=245&rft.pages=241-245&rft.issn=2049-9434&rft.eissn=2049-9442&rft_id=info:doi/10.3892/br.2015.553&rft_dat=%3Cgale_pubme%3EA444866777%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1930925405&rft_id=info:pmid/26893846&rft_galeid=A444866777&rfr_iscdi=true |