Porcine Epidemic Diarrhea Virus 3C-Like Protease Regulates Its Interferon Antagonism by Cleaving NEMO

Porcine epidemic diarrhea virus (PEDV) is an enteropathogenic coronavirus causing lethal watery diarrhea in piglets. Since 2010, a PEDV variant has spread rapidly in China, and it emerged in the United States in 2013, posing significant economic and public health concerns. The ability to circumvent...

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Veröffentlicht in:	Journal of virology 2016-02, Vol.90 (4), p.2090-2101
Hauptverfasser:	Wang, Dang, Fang, Liurong, Shi, Yanling, Zhang, Huan, Gao, Li, Peng, Guiqing, Chen, Huanchun, Li, Kui, Xiao, Shaobo
Format:	Artikel
Sprache:	eng
Schlagworte:	3C Viral Proteases Animals Cell Line Cellular Response to Infection Coronavirus Cysteine Endopeptidases - genetics Cysteine Endopeptidases - metabolism DNA Mutational Analysis Host-Pathogen Interactions Humans I-kappa B Kinase - metabolism Immune Evasion Interferons - antagonists & inhibitors Picornavirus Porcine epidemic diarrhea virus Porcine epidemic diarrhea virus - enzymology Porcine epidemic diarrhea virus - genetics Porcine epidemic diarrhea virus - immunology Proteolysis Viral Proteins - genetics Viral Proteins - metabolism
Online-Zugang:	Volltext
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