Submolecular regulation of cell transformation by deuterium depleting water exchange reactions in the tricarboxylic acid substrate cycle

Abstract The naturally occurring isotope of hydrogen (1 H), deuterium (2 H), could have an important biological role. Deuterium depleted water delays tumor progression in mice, dogs, cats and humans. Hydratase enzymes of the tricarboxylic acid (TCA) cycle control cell growth and deplete deuterium fr...

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Veröffentlicht in:	Medical hypotheses 2016-02, Vol.87, p.69-74
Hauptverfasser:	Boros, László G, D’Agostino, Dominic P, Katz, Howard E, Roth, Justine P, Meuillet, Emmanuelle J, Somlyai, Gábor
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Proliferation Cell Transformation, Neoplastic - drug effects Cell Transformation, Neoplastic - metabolism Citric Acid Cycle - drug effects Deuterium - metabolism Deuterium - pharmacology Electron Transport Humans Internal Medicine Metabolome Mice Mitochondria - metabolism Models, Biological Water - metabolism
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