REST represses a subset of the pancreatic endocrine differentiation program

To contribute to devise successful beta-cell differentiation strategies for the cure of Type 1 diabetes we sought to uncover barriers that restrict endocrine fate acquisition by studying the role of the transcriptional repressor REST in the developing pancreas. Rest expression is prevented in neuron...

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Veröffentlicht in:	Developmental biology 2015-09, Vol.405 (2), p.316-327
Hauptverfasser:	Martin, David, Kim, Yung-Hae, Sever, Dror, Mao, Chai-An, Haefliger, Jacques-Antoine, Grapin-Botton, Anne
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Beta cells Blood Glucose - metabolism Cell Differentiation Diabetes Down-Regulation Endocrine Cells - cytology Endocrine Cells - metabolism Endocrine System - metabolism Gene Deletion Gene Expression Regulation, Developmental Homeodomain Proteins - metabolism Islets Islets of Langerhans - metabolism Mice Mice, Knockout Neurons - metabolism NRSF Pancreas Pancreas - embryology Pancreas - metabolism Repressor Repressor Proteins - physiology Stem Cells - cytology Trans-Activators - metabolism Transgenes
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