Invasive Cell Fate Requires G1 Cell-Cycle Arrest and Histone Deacetylase-Mediated Changes in Gene Expression

Despite critical roles in development and cancer, the mechanisms that specify invasive cellular behavior are poorly understood. Through a screen of transcription factors in Caenorhabditis elegans, we identified G1 cell-cycle arrest as a precisely regulated requirement of the anchor cell (AC) invasio...

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Veröffentlicht in:	Developmental cell 2015-10, Vol.35 (2), p.162-174
Hauptverfasser:	Matus, David Q., Lohmer, Lauren L., Kelley, Laura C., Schindler, Adam J., Kohrman, Abraham Q., Barkoulas, Michalis, Zhang, Wan, Chi, Qiuyi, Sherwood, David R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - genetics Actins - metabolism Animals Caenorhabditis elegans - genetics Caenorhabditis elegans - growth & development Caenorhabditis elegans Proteins - biosynthesis Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism Cell Differentiation - genetics Cyclin-Dependent Kinase Inhibitor Proteins - genetics Cyclin-Dependent Kinase Inhibitor Proteins - metabolism G1 Phase Cell Cycle Checkpoints - genetics Gene Expression Regulation, Developmental Histone Deacetylases - biosynthesis Histone Deacetylases - genetics Neoplasm Invasiveness - genetics Neoplasm Invasiveness - pathology Podosomes - genetics Receptors, Cytoplasmic and Nuclear - genetics Receptors, Cytoplasmic and Nuclear - metabolism
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