Failure of a heterologous recombinant Sca5/OmpB protein-based vaccine to elicit effective protective immunity against Rickettsia rickettsii infections in C3H/HeN mice

Spotted fever group (SFG) rickettsial species are obligate intracellular tick-borne pathogens that are responsible for important human diseases. Previous reports have demonstrated the feasibility of using recombinant surface cell antigen Sca5/OmpB to elicit protective immunity against homologous cha...

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Veröffentlicht in:	Pathogens and disease 2015-12, Vol.73 (9), p.ftv101-ftv101
Hauptverfasser:	Riley, Sean P., Cardwell, Marissa M., Chan, Yvonne G.Y., Pruneau, Ludovic, Del Piero, Fabio, Martinez, Juan J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Antibodies, Bacterial - blood Antigens Antigens, Bacterial - genetics Antigens, Bacterial - immunology Bacterial diseases Bacterial Outer Membrane Proteins - genetics Bacterial Outer Membrane Proteins - immunology Bacterial Vaccines - administration & dosage Bacterial Vaccines - genetics Bacterial Vaccines - immunology Cross Protection Cross Reactions Disease Models, Animal Feasibility Homology Human behavior Immune response (humoral) Immunity Immunization Life Sciences Male Mediterranean spotted fever Mice Mice, Inbred C3H Mountains OmpB protein Protected animals Proteins Rickettsia conorii - genetics Rickettsia conorii - immunology Rickettsia rickettsii - genetics Rickettsia rickettsii - immunology Rocky Mountain spotted fever Rocky Mountain Spotted Fever - immunology Rocky Mountain Spotted Fever - prevention & control Species Survival Analysis Vaccination Vaccines Vaccines, Subunit - administration & dosage Vaccines, Subunit - genetics Vaccines, Subunit - immunology Vaccines, Synthetic - administration & dosage Vaccines, Synthetic - genetics Vaccines, Synthetic - immunology
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