Restoration of Corticosteroid Sensitivity in Chronic Obstructive Pulmonary Disease by Inhibition of Mammalian Target of Rapamycin

Corticosteroid resistance is a major barrier to the effective treatment of chronic obstructive pulmonary disease (COPD). Several molecular mechanisms have been proposed, such as activations of the phosphoinositide-3-kinase/Akt pathway and p38 mitogen-activated protein kinase. However, the mechanism...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 2016-01, Vol.193 (2), p.143-153
Hauptverfasser:	Mitani, Akihisa, Ito, Kazuhiro, Vuppusetty, Chaitanya, Barnes, Peter J, Mercado, Nicolas
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Cortex Hormones - pharmacology Adrenal Cortex Hormones - therapeutic use Aged Drug Resistance - drug effects Drug Resistance - immunology Female Histone Deacetylase 2 - drug effects Histone Deacetylase 2 - physiology Humans Immunosuppressive Agents - immunology Immunosuppressive Agents - pharmacology Immunosuppressive Agents - therapeutic use Male Middle Aged Original Oxidative Stress - drug effects Oxidative Stress - physiology p38 Mitogen-Activated Protein Kinases - drug effects p38 Mitogen-Activated Protein Kinases - physiology Phosphatidylinositol 3-Kinases - drug effects Phosphatidylinositol 3-Kinases - physiology Proto-Oncogene Proteins c-akt - drug effects Proto-Oncogene Proteins c-akt - physiology Proto-Oncogene Proteins c-jun - drug effects Proto-Oncogene Proteins c-jun - physiology Pulmonary Disease, Chronic Obstructive - drug therapy Pulmonary Disease, Chronic Obstructive - immunology Pulmonary Disease, Chronic Obstructive - physiopathology Sirolimus - immunology Sirolimus - pharmacology Sirolimus - therapeutic use Smoking - adverse effects Smoking - physiopathology TOR Serine-Threonine Kinases - drug effects TOR Serine-Threonine Kinases - physiology U937 Cells - drug effects
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