A Synergistic Role of Myeloperoxidase and High Sensitivity Troponin T in the Early Diagnosis of Acute Coronary Syndrome
Aim of this study was to evaluate the role of Myeloperoxidase (MPO) and high sensitive Troponin T in the early diagnosis of acute coronary syndrome (ACS). This was a cross sectional study that comprised of 120 individuals of which 75 were cases and 45 healthy controls. On the basis of clinical histo...
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| Veröffentlicht in: | Indian journal of clinical biochemistry 2016-03, Vol.31 (1), p.75-80 |
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| creator | Mehta, Mihir D. Marwah, Simbita A. Ghosh, S. Shah, Hitesh Trivedi, Amit Haridas, N. |
| description | Aim of this study was to evaluate the role of Myeloperoxidase (MPO) and high sensitive Troponin T in the early diagnosis of acute coronary syndrome (ACS). This was a cross sectional study that comprised of 120 individuals of which 75 were cases and 45 healthy controls. On the basis of clinical history and 12 lead electrocardiogram initial diagnosis of ACS was made in the cases. MPO and high sensitive Troponin T (hs-cTnT) was measured in all the individuals. Levels of MPO were significantly higher in patients of ACS as compared to those in control group [medians: 15.40 (95 % CI 11.06–20.84) vs 5.84 (95 % CI 5.50–6.44)]. By taking the cut off as >11.87 U/mL for MPO, its sensitivity was 87 % (95 % CI 73.7–95.1), specificity was 97.3 % (95 % CI 90.6–99.7), positive predictive value was 94.6 % and negative predictive value was 92.6 %. Positive likelihood ratio was 33.0 while negative likelihood ratio was 0.13, whereas the corresponding values in case of hs-cTnT were 95.6 % (95 % CI 85.2–99.5), 61.3 % (95 % CI 49.5–72.6), 59.7 %, 95.8 %, 2.47 and 0.07 by taking cut off as >14 pg/ml. The area under the ROC curves (AUC) of MPO and hscTnT at 0–6 h were 0.971 (95 % CI 0.92–0.99, P |
| doi_str_mv | 10.1007/s12291-015-0490-4 |
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This was a cross sectional study that comprised of 120 individuals of which 75 were cases and 45 healthy controls. On the basis of clinical history and 12 lead electrocardiogram initial diagnosis of ACS was made in the cases. MPO and high sensitive Troponin T (hs-cTnT) was measured in all the individuals. Levels of MPO were significantly higher in patients of ACS as compared to those in control group [medians: 15.40 (95 % CI 11.06–20.84) vs 5.84 (95 % CI 5.50–6.44)]. By taking the cut off as >11.87 U/mL for MPO, its sensitivity was 87 % (95 % CI 73.7–95.1), specificity was 97.3 % (95 % CI 90.6–99.7), positive predictive value was 94.6 % and negative predictive value was 92.6 %. Positive likelihood ratio was 33.0 while negative likelihood ratio was 0.13, whereas the corresponding values in case of hs-cTnT were 95.6 % (95 % CI 85.2–99.5), 61.3 % (95 % CI 49.5–72.6), 59.7 %, 95.8 %, 2.47 and 0.07 by taking cut off as >14 pg/ml. The area under the ROC curves (AUC) of MPO and hscTnT at 0–6 h were 0.971 (95 % CI 0.92–0.99, P < 0.001) and 0.797 (95 % CI 0.71–0.86, P < 0.001) respectively. The logistic model combining the two markers yielded sensitivity, specificity, positive predictive value and negative predictive value of 95.7, 97.3, 98.2 and 93.7 % respectively. It was concluded that MPO and hs-cTnT may be useful tools for risk stratification of ACS and can be used together with better accuracy in the early diagnosis of ACS.</description><identifier>ISSN: 0970-1915</identifier><identifier>EISSN: 0974-0422</identifier><identifier>DOI: 10.1007/s12291-015-0490-4</identifier><identifier>PMID: 26855491</identifier><language>eng</language><publisher>New Delhi: Springer India</publisher><subject>Acute coronary syndromes ; Biochemistry ; Biomarkers ; Biomedical and Life Sciences ; Chemistry/Food Science ; Coronary heart disease ; Diagnosis ; Enzymes ; Life Sciences ; Medical diagnosis ; Microbiology ; Original ; Original Article ; Pathology</subject><ispartof>Indian journal of clinical biochemistry, 2016-03, Vol.31 (1), p.75-80</ispartof><rights>Association of Clinical Biochemists of India 2015</rights><rights>COPYRIGHT 2016 Springer</rights><rights>Association of Clinical Biochemists of India 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c571t-6bd096091331ecc8e72750aec020804f9a118cba70275972d6d06817fe3c5c283</citedby><cites>FETCH-LOGICAL-c571t-6bd096091331ecc8e72750aec020804f9a118cba70275972d6d06817fe3c5c283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731358/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731358/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,41488,42557,51319,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26855491$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mehta, Mihir D.</creatorcontrib><creatorcontrib>Marwah, Simbita A.</creatorcontrib><creatorcontrib>Ghosh, S.</creatorcontrib><creatorcontrib>Shah, Hitesh</creatorcontrib><creatorcontrib>Trivedi, Amit</creatorcontrib><creatorcontrib>Haridas, N.</creatorcontrib><title>A Synergistic Role of Myeloperoxidase and High Sensitivity Troponin T in the Early Diagnosis of Acute Coronary Syndrome</title><title>Indian journal of clinical biochemistry</title><addtitle>Ind J Clin Biochem</addtitle><addtitle>Indian J Clin Biochem</addtitle><description>Aim of this study was to evaluate the role of Myeloperoxidase (MPO) and high sensitive Troponin T in the early diagnosis of acute coronary syndrome (ACS). This was a cross sectional study that comprised of 120 individuals of which 75 were cases and 45 healthy controls. On the basis of clinical history and 12 lead electrocardiogram initial diagnosis of ACS was made in the cases. MPO and high sensitive Troponin T (hs-cTnT) was measured in all the individuals. Levels of MPO were significantly higher in patients of ACS as compared to those in control group [medians: 15.40 (95 % CI 11.06–20.84) vs 5.84 (95 % CI 5.50–6.44)]. By taking the cut off as >11.87 U/mL for MPO, its sensitivity was 87 % (95 % CI 73.7–95.1), specificity was 97.3 % (95 % CI 90.6–99.7), positive predictive value was 94.6 % and negative predictive value was 92.6 %. Positive likelihood ratio was 33.0 while negative likelihood ratio was 0.13, whereas the corresponding values in case of hs-cTnT were 95.6 % (95 % CI 85.2–99.5), 61.3 % (95 % CI 49.5–72.6), 59.7 %, 95.8 %, 2.47 and 0.07 by taking cut off as >14 pg/ml. The area under the ROC curves (AUC) of MPO and hscTnT at 0–6 h were 0.971 (95 % CI 0.92–0.99, P < 0.001) and 0.797 (95 % CI 0.71–0.86, P < 0.001) respectively. The logistic model combining the two markers yielded sensitivity, specificity, positive predictive value and negative predictive value of 95.7, 97.3, 98.2 and 93.7 % respectively. It was concluded that MPO and hs-cTnT may be useful tools for risk stratification of ACS and can be used together with better accuracy in the early diagnosis of ACS.</description><subject>Acute coronary syndromes</subject><subject>Biochemistry</subject><subject>Biomarkers</subject><subject>Biomedical and Life Sciences</subject><subject>Chemistry/Food Science</subject><subject>Coronary heart disease</subject><subject>Diagnosis</subject><subject>Enzymes</subject><subject>Life Sciences</subject><subject>Medical diagnosis</subject><subject>Microbiology</subject><subject>Original</subject><subject>Original Article</subject><subject>Pathology</subject><issn>0970-1915</issn><issn>0974-0422</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kk1v1DAQhiMEoqXwA7ggS1zKIWXsOHFyQVothVYqQuouZ8vrTLKuEnuxk9L8exy2lC4CWfLH-Jl3_PEmyWsKZxRAvA-UsYqmQPMUeAUpf5IcQyV4XDH29NccUlrR_Ch5EcINQMaB0-fJESvKPOcVPU5-LMhqsuhbEwajybXrkLiGfJmwczv07s7UKiBRtiYXpt2SFdpgBnNrhomsvds5ayxZk9gNWyTnyncT-WhUa10wYVZa6HFAsnTeWeWnuVjtXY8vk2eN6gK-uh9Pkm-fztfLi_Tq6-fL5eIq1bmgQ1psaqgKqGiWUdS6RMFEDgo1MCiBN5WitNQbJSDGK8HqooaipKLBTOealdlJ8mGvuxs3PdYa7eBVJ3fe9PE40ikjD3es2crW3UouMprls8DpvYB330cMg-xN0Nh1yqIbg6Si4FlWFnkR0bd_oTdu9DZeb6Yo8KIo4Q_Vqg6lsY2LdfUsKheC8vhDjM_U2T-o2GrsjXYWGxPjBwnvDhIiM-Dd0KoxBHm5uj5k6Z7V3oXgsXl4DwpydpbcO0tGZ8nZWZLHnDePH_Ih47eVIsD2QIhbtkX_6Pb_Vf0JAfPWxg</recordid><startdate>20160301</startdate><enddate>20160301</enddate><creator>Mehta, Mihir D.</creator><creator>Marwah, Simbita A.</creator><creator>Ghosh, S.</creator><creator>Shah, Hitesh</creator><creator>Trivedi, Amit</creator><creator>Haridas, N.</creator><general>Springer India</general><general>Springer</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>04Q</scope><scope>04W</scope><scope>3V.</scope><scope>7XB</scope><scope>88A</scope><scope>88I</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160301</creationdate><title>A Synergistic Role of Myeloperoxidase and High Sensitivity Troponin T in the Early Diagnosis of Acute Coronary Syndrome</title><author>Mehta, Mihir D. ; Marwah, Simbita A. ; Ghosh, S. ; Shah, Hitesh ; Trivedi, Amit ; Haridas, N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c571t-6bd096091331ecc8e72750aec020804f9a118cba70275972d6d06817fe3c5c283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Acute coronary syndromes</topic><topic>Biochemistry</topic><topic>Biomarkers</topic><topic>Biomedical and Life Sciences</topic><topic>Chemistry/Food Science</topic><topic>Coronary heart disease</topic><topic>Diagnosis</topic><topic>Enzymes</topic><topic>Life Sciences</topic><topic>Medical diagnosis</topic><topic>Microbiology</topic><topic>Original</topic><topic>Original Article</topic><topic>Pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mehta, Mihir D.</creatorcontrib><creatorcontrib>Marwah, Simbita A.</creatorcontrib><creatorcontrib>Ghosh, S.</creatorcontrib><creatorcontrib>Shah, Hitesh</creatorcontrib><creatorcontrib>Trivedi, Amit</creatorcontrib><creatorcontrib>Haridas, N.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>India Database</collection><collection>India Database: Science & Technology</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Indian journal of clinical biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mehta, Mihir D.</au><au>Marwah, Simbita A.</au><au>Ghosh, S.</au><au>Shah, Hitesh</au><au>Trivedi, Amit</au><au>Haridas, N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Synergistic Role of Myeloperoxidase and High Sensitivity Troponin T in the Early Diagnosis of Acute Coronary Syndrome</atitle><jtitle>Indian journal of clinical biochemistry</jtitle><stitle>Ind J Clin Biochem</stitle><addtitle>Indian J Clin Biochem</addtitle><date>2016-03-01</date><risdate>2016</risdate><volume>31</volume><issue>1</issue><spage>75</spage><epage>80</epage><pages>75-80</pages><issn>0970-1915</issn><eissn>0974-0422</eissn><abstract>Aim of this study was to evaluate the role of Myeloperoxidase (MPO) and high sensitive Troponin T in the early diagnosis of acute coronary syndrome (ACS). This was a cross sectional study that comprised of 120 individuals of which 75 were cases and 45 healthy controls. On the basis of clinical history and 12 lead electrocardiogram initial diagnosis of ACS was made in the cases. MPO and high sensitive Troponin T (hs-cTnT) was measured in all the individuals. Levels of MPO were significantly higher in patients of ACS as compared to those in control group [medians: 15.40 (95 % CI 11.06–20.84) vs 5.84 (95 % CI 5.50–6.44)]. By taking the cut off as >11.87 U/mL for MPO, its sensitivity was 87 % (95 % CI 73.7–95.1), specificity was 97.3 % (95 % CI 90.6–99.7), positive predictive value was 94.6 % and negative predictive value was 92.6 %. Positive likelihood ratio was 33.0 while negative likelihood ratio was 0.13, whereas the corresponding values in case of hs-cTnT were 95.6 % (95 % CI 85.2–99.5), 61.3 % (95 % CI 49.5–72.6), 59.7 %, 95.8 %, 2.47 and 0.07 by taking cut off as >14 pg/ml. The area under the ROC curves (AUC) of MPO and hscTnT at 0–6 h were 0.971 (95 % CI 0.92–0.99, P < 0.001) and 0.797 (95 % CI 0.71–0.86, P < 0.001) respectively. The logistic model combining the two markers yielded sensitivity, specificity, positive predictive value and negative predictive value of 95.7, 97.3, 98.2 and 93.7 % respectively. It was concluded that MPO and hs-cTnT may be useful tools for risk stratification of ACS and can be used together with better accuracy in the early diagnosis of ACS.</abstract><cop>New Delhi</cop><pub>Springer India</pub><pmid>26855491</pmid><doi>10.1007/s12291-015-0490-4</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acute coronary syndromes Biochemistry Biomarkers Biomedical and Life Sciences Chemistry/Food Science Coronary heart disease Diagnosis Enzymes Life Sciences Medical diagnosis Microbiology Original Original Article Pathology |
| title | A Synergistic Role of Myeloperoxidase and High Sensitivity Troponin T in the Early Diagnosis of Acute Coronary Syndrome |
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