Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma

Jessica Okosun, David Sabatini and colleagues identify recurrent RRAGC mutations in follicular lymphoma, resulting in activated mTORC1 signaling. The activating nature of the mutations, their existence within the dominant clone and their stability during disease progression support the potential of...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature genetics 2016-02, Vol.48 (2), p.183-188
Hauptverfasser:	Okosun, Jessica, Wolfson, Rachel L, Wang, Jun, Araf, Shamzah, Wilkins, Lucy, Castellano, Brian M, Escudero-Ibarz, Leire, Al Seraihi, Ahad Fahad, Richter, Julia, Bernhart, Stephan H, Efeyan, Alejo, Iqbal, Sameena, Matthews, Janet, Clear, Andrew, Guerra-Assunção, José Afonso, Bödör, Csaba, Quentmeier, Hilmar, Mansbridge, Christopher, Johnson, Peter, Davies, Andrew, Strefford, Jonathan C, Packham, Graham, Barrans, Sharon, Jack, Andrew, Du, Ming-Qing, Calaminici, Maria, Lister, T Andrew, Auer, Rebecca, Montoto, Silvia, Gribben, John G, Siebert, Reiner, Chelala, Claude, Zoncu, Roberto, Sabatini, David M, Fitzgibbon, Jude
Format:	Artikel
Sprache:	eng
Schlagworte:	45/23 45/44 45/91 631/208/212 692/699/1541/1990/291 Agriculture Amino Acid Sequence Amino acids Animal Genetics and Genomics Animals Biomedicine Blood diseases Cancer Cancer Research Cloning Deoxyribonucleic acid Development and progression DNA Gene Function Gene mutations Genetic aspects Genomes Health aspects Hematology Human Genetics Humans Hypotheses Identification and classification letter Lymphoma Lymphoma, Follicular - genetics Lymphomas Mechanistic Target of Rapamycin Complex 1 Medical research Molecular Sequence Data Monomeric GTP-Binding Proteins - chemistry Monomeric GTP-Binding Proteins - genetics Multiprotein Complexes - chemistry Multiprotein Complexes - genetics Mutation Phosphotransferases Scholarships & fellowships Sequence Homology, Amino Acid TOR Serine-Threonine Kinases - chemistry TOR Serine-Threonine Kinases - genetics Translocation Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!