The evolving roles of canonical WNT signaling in stem cells and tumorigenesis: implications in targeted cancer therapies

The canonical WNT/β-catenin signaling pathway governs a myriad of biological processes underlying the development and maintenance of adult tissue homeostasis, including regulation of stem cell self-renewal, cell proliferation, differentiation, and apoptosis. WNTs are secreted lipid-modified glycopro...

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Veröffentlicht in:	Laboratory investigation 2016-02, Vol.96 (2), p.116-136
Hauptverfasser:	Yang, Ke, Wang, Xin, Zhang, Hongmei, Wang, Zhongliang, Nan, Guoxin, Li, Yasha, Zhang, Fugui, Mohammed, Maryam K, Haydon, Rex C, Luu, Hue H, Bi, Yang, He, Tong-Chuan
Format:	Artikel
Sprache:	eng
Schlagworte:	13/95 45/100 631/67 631/67/1059 Animals Carcinogenesis Drug Discovery Humans Laboratory Medicine Medicine Medicine & Public Health Mice Neoplasms - drug therapy pathobiology-in-focus Pathology Stem Cells Wnt Proteins Wnt Signaling Pathway
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