Wnt5a induces ROR1/ROR2 heterooligomerization to enhance leukemia chemotaxis and proliferation

Evolutionarily conserved receptor tyrosine kinase–like orphan receptor-1 and -2 (ROR1/2) are considered distinct receptors for Wnt5a and are implicated in noncanonical Wnt signaling in organogenesis and cancer metastasis. We found that Wnt5a enhanced proliferation and migration of chronic lymphocyti...

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Veröffentlicht in:	The Journal of clinical investigation 2016-02, Vol.126 (2), p.585-598
Hauptverfasser:	Yu, Jian, Chen, Liguang, Cui, Bing, Widhopf, 2nd, George F, Shen, Zhouxin, Wu, Rongrong, Zhang, Ling, Zhang, Suping, Briggs, Steven P, Kipps, Thomas J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical research Cancer Cell growth Cell Proliferation Cell receptors Chemotaxis Development and progression Flow cytometry Genetic aspects Health aspects Heterografts Humans Kinases Laboratory animals Leukemia Leukemia, Lymphocytic, Chronic, B-Cell - genetics Leukemia, Lymphocytic, Chronic, B-Cell - metabolism Leukemia, Lymphocytic, Chronic, B-Cell - pathology Medical research Metastasis Mice Mice, Knockout Microscopy Neoplasm Transplantation Protein Multimerization Proteins Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism rac1 GTP-Binding Protein - genetics rac1 GTP-Binding Protein - metabolism Receptor Tyrosine Kinase-like Orphan Receptors - genetics Receptor Tyrosine Kinase-like Orphan Receptors - metabolism Software Spleen Wnt Proteins - genetics Wnt Proteins - metabolism Wnt-5a Protein
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