Synthesis and activity of a novel inhibitor of nonsense-mediated mRNA decay† †Electronic supplementary information (ESI) available: Experimental procedures and spectroscopic data. See DOI: 10.1039/c5ob02482j Click here for additional data file

A new route to a tetracyclic lactam was developed and the product, called VG1 , was found to inhibit nonsense-mediated mRNA decay at μM concentrations. During efforts to prepare the known compound NMDI1 , a new tetracyclic compound, called VG1 , was prepared in six steps. This compound was found to...

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Veröffentlicht in:	Organic & biomolecular chemistry 2016-01, Vol.14 (5), p.1559-1563
Hauptverfasser:	Gotham, Victoria J. B., Hobbs, Melanie C., Burgin, Ryan, Turton, David, Smythe, Carl, Coldham, Iain
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry
Online-Zugang:	Volltext
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