The fibroblast Tiam1-osteopontin pathway modulates breast cancer invasion and metastasis

The tumor microenvironment has complex effects in cancer pathophysiology that are not fully understood. Most cancer therapies are directed against malignant cells specifically, leaving pro-malignant signals from the microenvironment unaddressed. Defining specific mechanisms by which the tumor microe...

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Veröffentlicht in:	Breast cancer research : BCR 2016-01, Vol.18 (1), p.14-14, Article 14
Hauptverfasser:	Xu, Kun, Tian, Xuejun, Oh, Sun Y, Movassaghi, Mohammad, Naber, Stephen P, Kuperwasser, Charlotte, Buchsbaum, Rachel J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Breast cancer Breast Neoplasms - genetics Breast Neoplasms - pathology Cell Line, Tumor Cellular signal transduction Coculture Techniques Development and progression Epithelial-Mesenchymal Transition - genetics Female Fibroblasts Fibroblasts - metabolism Genetic aspects Guanine Nucleotide Exchange Factors - biosynthesis Guanine Nucleotide Exchange Factors - genetics Humans Lung Neoplasms - genetics Lung Neoplasms - pathology Lung Neoplasms - secondary Metastasis Mice Neoplasm Invasiveness - genetics Neoplasm Metastasis Osteopontin - biosynthesis Osteopontin - genetics Physiological aspects Signal Transduction Stromal Cells - pathology T-Lymphoma Invasion and Metastasis-inducing Protein 1 Tumor Microenvironment - genetics Xenograft Model Antitumor Assays
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