Glyceollin I Reverses Epithelial to Mesenchymal Transition in Letrozole Resistant Breast Cancer through ZEB1

Although aromatase inhibitors are standard endocrine therapy for postmenopausal women with early-stage metastatic estrogen-dependent breast cancer, they are limited by the development of drug resistance. A better understanding of this process is critical towards designing novel strategies for diseas...

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Veröffentlicht in:	International journal of environmental research and public health 2015-12, Vol.13 (1), p.ijerph13010010-ijerph13010010
Hauptverfasser:	Carriere, Patrick P, Llopis, Shawn D, Naiki, Anna C, Nguyen, Gina, Phan, Tina, Nguyen, Mary M, Preyan, Lynez C, Yearby, Letitia, Pratt, Jamal, Burks, Hope, Davenport, Ian R, Nguyen, Thu A, Parker-Lemieux, KiTani, Payton-Stewart, Florastina, Williams, Christopher C, Boué, Stephen M, Burow, Matthew E, Collins-Burow, Bridgette, Hilliard, Aaron, Davidson, A Michael, Tilghman, Syreeta L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - metabolism Antineoplastic Agents - therapeutic use Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - physiopathology Cell Line, Tumor - drug effects Cell Movement Drug Resistance, Neoplasm - drug effects Epithelial-Mesenchymal Transition - drug effects Female Fluorescence Genotype & phenotype Humans Metastasis Mice Mice, Nude Nitriles - metabolism Nitriles - therapeutic use Pterocarpans - metabolism Transcription Factors - metabolism Triazoles - metabolism Triazoles - therapeutic use
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