Free Radical Scavenging and Cellular Antioxidant Properties of Astaxanthin
Astaxanthin is a coloring agent which is used as a feed additive in aquaculture nutrition. Recently, potential health benefits of astaxanthin have been discussed which may be partly related to its free radical scavenging and antioxidant properties. Our electron spin resonance (ESR) and spin trapping...
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| Veröffentlicht in: | International journal of molecular sciences 2016-01, Vol.17 (1), p.103-103 |
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| creator | Dose, Janina Matsugo, Seiichi Yokokawa, Haruka Koshida, Yutaro Okazaki, Shigetoshi Seidel, Ulrike Eggersdorfer, Manfred Rimbach, Gerald Esatbeyoglu, Tuba |
| description | Astaxanthin is a coloring agent which is used as a feed additive in aquaculture nutrition. Recently, potential health benefits of astaxanthin have been discussed which may be partly related to its free radical scavenging and antioxidant properties. Our electron spin resonance (ESR) and spin trapping data suggest that synthetic astaxanthin is a potent free radical scavenger in terms of diphenylpicryl-hydrazyl (DPPH) and galvinoxyl free radicals. Furthermore, astaxanthin dose-dependently quenched singlet oxygen as determined by photon counting. In addition to free radical scavenging and singlet oxygen quenching properties, astaxanthin induced the antioxidant enzyme paroxoanase-1, enhanced glutathione concentrations and prevented lipid peroxidation in cultured hepatocytes. Present results suggest that, beyond its coloring properties, synthetic astaxanthin exhibits free radical scavenging, singlet oxygen quenching, and antioxidant activities which could probably positively affect animal and human health. |
| doi_str_mv | 10.3390/ijms17010103 |
| format | Article |
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Recently, potential health benefits of astaxanthin have been discussed which may be partly related to its free radical scavenging and antioxidant properties. Our electron spin resonance (ESR) and spin trapping data suggest that synthetic astaxanthin is a potent free radical scavenger in terms of diphenylpicryl-hydrazyl (DPPH) and galvinoxyl free radicals. Furthermore, astaxanthin dose-dependently quenched singlet oxygen as determined by photon counting. In addition to free radical scavenging and singlet oxygen quenching properties, astaxanthin induced the antioxidant enzyme paroxoanase-1, enhanced glutathione concentrations and prevented lipid peroxidation in cultured hepatocytes. Present results suggest that, beyond its coloring properties, synthetic astaxanthin exhibits free radical scavenging, singlet oxygen quenching, and antioxidant activities which could probably positively affect animal and human health.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms17010103</identifier><identifier>PMID: 26784174</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Antioxidants ; Cell Line ; Cellular biology ; Drug therapy ; Free Radical Scavengers - pharmacology ; Free radicals ; Hep G2 Cells ; Hepatocytes - drug effects ; Hepatocytes - metabolism ; Humans ; Lipid Peroxidation ; Xanthophylls - pharmacology</subject><ispartof>International journal of molecular sciences, 2016-01, Vol.17 (1), p.103-103</ispartof><rights>Copyright MDPI AG 2016</rights><rights>2016 by the authors; licensee MDPI, Basel, Switzerland. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c511t-241ca049e6714d7d0b3afa05d7269dc0bb53d4ab1bfd83d8d7e89e7f38bf5a5b3</citedby><cites>FETCH-LOGICAL-c511t-241ca049e6714d7d0b3afa05d7269dc0bb53d4ab1bfd83d8d7e89e7f38bf5a5b3</cites><orcidid>0000-0001-7888-4684</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730345/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730345/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26784174$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dose, Janina</creatorcontrib><creatorcontrib>Matsugo, Seiichi</creatorcontrib><creatorcontrib>Yokokawa, Haruka</creatorcontrib><creatorcontrib>Koshida, Yutaro</creatorcontrib><creatorcontrib>Okazaki, Shigetoshi</creatorcontrib><creatorcontrib>Seidel, Ulrike</creatorcontrib><creatorcontrib>Eggersdorfer, Manfred</creatorcontrib><creatorcontrib>Rimbach, Gerald</creatorcontrib><creatorcontrib>Esatbeyoglu, Tuba</creatorcontrib><title>Free Radical Scavenging and Cellular Antioxidant Properties of Astaxanthin</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Astaxanthin is a coloring agent which is used as a feed additive in aquaculture nutrition. Recently, potential health benefits of astaxanthin have been discussed which may be partly related to its free radical scavenging and antioxidant properties. Our electron spin resonance (ESR) and spin trapping data suggest that synthetic astaxanthin is a potent free radical scavenger in terms of diphenylpicryl-hydrazyl (DPPH) and galvinoxyl free radicals. Furthermore, astaxanthin dose-dependently quenched singlet oxygen as determined by photon counting. In addition to free radical scavenging and singlet oxygen quenching properties, astaxanthin induced the antioxidant enzyme paroxoanase-1, enhanced glutathione concentrations and prevented lipid peroxidation in cultured hepatocytes. Present results suggest that, beyond its coloring properties, synthetic astaxanthin exhibits free radical scavenging, singlet oxygen quenching, and antioxidant activities which could probably positively affect animal and human health.</description><subject>Antioxidants</subject><subject>Cell Line</subject><subject>Cellular biology</subject><subject>Drug therapy</subject><subject>Free Radical Scavengers - pharmacology</subject><subject>Free radicals</subject><subject>Hep G2 Cells</subject><subject>Hepatocytes - drug effects</subject><subject>Hepatocytes - metabolism</subject><subject>Humans</subject><subject>Lipid Peroxidation</subject><subject>Xanthophylls - pharmacology</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkctLxDAQxoMovm-epeDFg6tJJ22ai7Asrg8Excc5TJt0zdJN1qSV9b-3iw9WL5LDhJkf3zw-Qg4YPQWQ9MxOZ5EJyvoHa2Sb8TQdUJqL9ZX_FtmJcUppCmkmN8lWmouCM8G3yc04GJM8oLYVNsljhW_GTaybJOh0MjJN0zUYkqFrrV9Yja5N7oOfm9BaExNfJ8PY4qJPv1i3RzZqbKLZ_4q75Hl88TS6GtzeXV6PhreDKmOsHaScVUi5NLlgXAtNS8AaaaZFmktd0bLMQHMsWVnrAnShhSmkETUUZZ1hVsIuOf_UnXflzOjKuDZgo-bBzjC8K49W_a44-6Im_k1xARR41gscfwkE_9qZ2KqZjVW_Kzrju6hYAQKYyKX8HxU5LWROYYke_UGnvguuv0RPyRzSgsOy98knVQUfYzD1z9yMqqWfatXPHj9c3fUH_jYQPgCOrpxL</recordid><startdate>20160114</startdate><enddate>20160114</enddate><creator>Dose, Janina</creator><creator>Matsugo, Seiichi</creator><creator>Yokokawa, Haruka</creator><creator>Koshida, Yutaro</creator><creator>Okazaki, Shigetoshi</creator><creator>Seidel, Ulrike</creator><creator>Eggersdorfer, Manfred</creator><creator>Rimbach, Gerald</creator><creator>Esatbeyoglu, Tuba</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>7TK</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7888-4684</orcidid></search><sort><creationdate>20160114</creationdate><title>Free Radical Scavenging and Cellular Antioxidant Properties of Astaxanthin</title><author>Dose, Janina ; 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Recently, potential health benefits of astaxanthin have been discussed which may be partly related to its free radical scavenging and antioxidant properties. Our electron spin resonance (ESR) and spin trapping data suggest that synthetic astaxanthin is a potent free radical scavenger in terms of diphenylpicryl-hydrazyl (DPPH) and galvinoxyl free radicals. Furthermore, astaxanthin dose-dependently quenched singlet oxygen as determined by photon counting. In addition to free radical scavenging and singlet oxygen quenching properties, astaxanthin induced the antioxidant enzyme paroxoanase-1, enhanced glutathione concentrations and prevented lipid peroxidation in cultured hepatocytes. 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| subjects | Antioxidants Cell Line Cellular biology Drug therapy Free Radical Scavengers - pharmacology Free radicals Hep G2 Cells Hepatocytes - drug effects Hepatocytes - metabolism Humans Lipid Peroxidation Xanthophylls - pharmacology |
| title | Free Radical Scavenging and Cellular Antioxidant Properties of Astaxanthin |
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