Coagulation factor XIIIa is inactivated by plasmin

Coagulation factor XIIIa (FXIIIa) is a transglutaminase that covalently cross-links fibrin and other proteins to fibrin to stabilize blood clots and reduce blood loss. A clear mechanism to describe the physiological inactivation of FXIIIa has been elusive. Here, we show that plasmin can cleave FXIII...

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Veröffentlicht in:	Blood 2015-11, Vol.126 (20), p.2329-2337
Hauptverfasser:	Hur, Woosuk S., Mazinani, Nima, Lu, X. J. David, Britton, Heidi M., Byrnes, James R., Wolberg, Alisa S., Kastrup, Christian J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Factor XIII - chemistry Factor XIII - metabolism Fibrinolysin - chemistry Fibrinolysin - metabolism Fibrinolysis - physiology Humans Proteolysis Thrombosis and Hemostasis Tissue Plasminogen Activator - chemistry Tissue Plasminogen Activator - metabolism
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