Novel Wnt Regulator NEL-Like Molecule-1 Antagonizes Adipogenesis and Augments Osteogenesis Induced by Bone Morphogenetic Protein 2

The differentiation factor NEL-like molecule-1 (NELL-1) has been reported as osteoinductive in multiple in vivo preclinical models. Bone morphogenetic protein (BMP)-2 is used clinically for skeletal repair, but in vivo administration can induce abnormal, adipose-filled, poor-quality bone. We demonst...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	The American journal of pathology 2016-02, Vol.186 (2), p.419-434
Hauptverfasser:	Shen, Jia, James, Aaron W, Zhang, Xinli, Pang, Shen, Zara, Janette N, Asatrian, Greg, Chiang, Michael, Lee, Min, Khadarian, Kevork, Nguyen, Alan, Lee, Kevin S, Siu, Ronald K, Tetradis, Sotirios, Ting, Kang, Soo, Chia
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipogenesis Animals Bone Morphogenetic Protein 2 - metabolism Bone Regeneration - physiology Humans Male Mesenchymal Stromal Cells - metabolism Nerve Tissue Proteins - metabolism Osteogenesis - physiology Pathology Rats, Inbred Lew Regular Signal Transduction - physiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!