Bile Acid Signaling Is Involved in the Neurological Decline in a Murine Model of Acute Liver Failure

Hepatic encephalopathy is a serious neurological complication of liver failure. Serum bile acids are elevated after liver damage and may disrupt the blood-brain barrier and enter the brain. Our aim was to assess the role of serum bile acids in the neurological complications after acute liver failure...

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Veröffentlicht in:	The American journal of pathology 2016-02, Vol.186 (2), p.312-323
Hauptverfasser:	McMillin, Matthew, Frampton, Gabriel, Quinn, Matthew, Ashfaq, Samir, de los Santos, Mario, Grant, Stephanie, DeMorrow, Sharon
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bile Acids and Salts - metabolism Blood-Brain Barrier - metabolism Central Nervous System Diseases - etiology Cholesterol 7-alpha-Hydroxylase - genetics Cholic Acid - metabolism Disease Models, Animal Liver Failure, Acute - complications Liver Failure, Acute - genetics Liver Failure, Acute - metabolism Mice, Inbred C57BL Mice, Knockout Organic Anion Transporters, Sodium-Dependent - genetics Organic Anion Transporters, Sodium-Dependent - metabolism Pathology Regular Signal Transduction - genetics Signal Transduction - physiology Symporters - genetics Symporters - metabolism
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