metilene: fast and sensitive calling of differentially methylated regions from bisulfite sequencing data

The detection of differentially methylated regions (DMRs) is a necessary prerequisite for characterizing different epigenetic states. We present a novel program, metilene, to identify DMRs within whole-genome and targeted data with unrivaled specificity and sensitivity. A binary segmentation algorit...

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Veröffentlicht in:	Genome research 2016-02, Vol.26 (2), p.256-262
Hauptverfasser:	Jühling, Frank, Kretzmer, Helene, Bernhart, Stephan H, Otto, Christian, Stadler, Peter F, Hoffmann, Steve
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Biochemistry, Molecular Biology Case-Control Studies Cerebellar Neoplasms - genetics CpG Islands DNA Methylation Genomics Humans Life Sciences Medulloblastoma - genetics Method Quantitative Methods Sequence Analysis, DNA Software
Online-Zugang:	Volltext
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