P2Y12 antagonist attenuates eosinophilic inflammation and airway hyperresponsiveness in a mouse model of asthma

Leukotriene E4 (LTE4) that plays a key role in airway inflammation is expressed on platelets and eosinophils. We investigated whether blocking of the P2Y12 receptor can suppress eosinophilic inflammation in a mouse model of asthma because platelets and eosinophils share this receptor to be activated...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2016-02, Vol.20 (2), p.333-341
Hauptverfasser:	Suh, Dong‐Hyeon, Trinh, Hoang Kim Tu, Liu, Jing‐Nan, Pham, Le Duy, Park, Sang Myun, Park, Hae‐Sim, Shin, Yoo Seob
Format:	Artikel
Sprache:	eng
Schlagworte:	Alveoli Animals Asthma Asthma - metabolism Asthma - pathology Bronchial Hyperreactivity - metabolism Bronchial Hyperreactivity - pathology Bronchoalveolar Lavage Fluid Bronchus Cell activation Clopidogrel Cytokines Cytokines - metabolism Disease Models, Animal eosinophil Eosinophil cationic protein Eosinophils - metabolism Eosinophils - pathology Female Goblet cells Inflammation Inflammation - metabolism Inflammation - pathology Injection Leukocytes (eosinophilic) leukotriene E4 Lungs Lymphocytes T Mice Mice, Inbred BALB C Mucus Original Ovalbumin Ovalbumin - pharmacology P2Y12 receptor Platelets Receptors, Purinergic P2Y12 - metabolism Respiratory tract Respiratory tract diseases Rodents Stimulation
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