Restoring the youth of aged red blood cells and extending their lifespan in circulation by remodelling membrane sialic acid

Membrane sialic acid (SA) plays an important role in the survival of red blood cells (RBCs), the age‐related reduction in SA content negatively impacts both the structure and function of these cells. We have therefore suggested that remodelling the SA in the membrane of aged cells would help recover...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2016-02, Vol.20 (2), p.294-301
Hauptverfasser:	Huang, Yao‐Xiong, Tuo, Wei‐Wei, Wang, Di, Kang, Li‐Li, Chen, Xing‐Yao, Luo, Man
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age aged red blood cell Animals Blood circulation CTP Cytidine triphosphate Erythrocyte Aging - physiology Erythrocyte Count - methods Erythrocyte Membrane - metabolism Erythrocyte Membrane - physiology Erythrocytes Erythrocytes - metabolism Erythrocytes - physiology extending lifespan Hemoglobin Humans Life span Male N-Acetylneuraminic Acid - metabolism Original Rabbits restoring youth sialic acid remodelling Structure-function relationships Young Adult
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