miR‐124 interacts with the Notch1 signalling pathway and has therapeutic potential against gastric cancer

Aberrant Notch signalling plays an important role in cancer progression. However, little is known about the interaction between miRNA and the Notch signalling pathway and its role in gastric cancer (GC). In this study, we found that miR‐124 was down‐regulated in GC compared with adjacent normal tiss...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2016-02, Vol.20 (2), p.313-322
Hauptverfasser:	Jiang, Lei, Lin, Tiesu, Xu, Chaochao, Hu, Sunkuan, Pan, Yangyang, Jin, Rong
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Amyloid Precursor Protein Secretases - genetics Cell cycle Cell growth Cell Line, Tumor Cell Movement - genetics Cell Proliferation - genetics Down-Regulation - genetics Feedback Female Gastric cancer Gene Expression Regulation, Neoplastic - genetics Humans intracellular domain of Notch1 JAG1 Male MicroRNAs - genetics Middle Aged miRNA miR‐124 Notch1 Notch1 protein Original Receptor, Notch1 - genetics Secretase Signal transduction Signal Transduction - genetics Stomach Neoplasms - genetics Up-Regulation - genetics
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