Lung cancer in which the hypothesis of multi-step progression is confirmed by array-CGH results: A case report
The pathogenesis of lung cancer has not been fully elucidated and biological markers acting as predictors of tumor evolution and aggressiveness remain unidentified. The multi-step hypothesis, suggesting a progression from adenomatous hyperplasia (AAH) to adenocarcinoma (AC) through bronchioalveolar...
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| Veröffentlicht in: | Experimental and therapeutic medicine 2016-01, Vol.11 (1), p.98-100 |
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| creator | BETTIO, DANIELA VENCI, ANNA ACHILLE, VALENTINA ALLOISIO, MARCO SANTORO, ARMANDO |
| description | The pathogenesis of lung cancer has not been fully elucidated and biological markers acting as predictors of tumor evolution and aggressiveness remain unidentified. The multi-step hypothesis, suggesting a progression from adenomatous hyperplasia (AAH) to adenocarcinoma (AC) through bronchioalveolar carcinoma (BAC), was highlighted in a previous cytogenetic study performed in a single case. The present study reports the results of an array-comparative genomic hybridization (a-CGH) analysis performed on the DNA obtained from the previously reported case that presented AAH, BAC and AC in one lung. The a-CGH results confirm and support the previous cytogenetic observations with new data, clearly supporting the hypothesis of a multi-step carcinogenic process in the lung. |
| doi_str_mv | 10.3892/etm.2015.2870 |
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The multi-step hypothesis, suggesting a progression from adenomatous hyperplasia (AAH) to adenocarcinoma (AC) through bronchioalveolar carcinoma (BAC), was highlighted in a previous cytogenetic study performed in a single case. The present study reports the results of an array-comparative genomic hybridization (a-CGH) analysis performed on the DNA obtained from the previously reported case that presented AAH, BAC and AC in one lung. The a-CGH results confirm and support the previous cytogenetic observations with new data, clearly supporting the hypothesis of a multi-step carcinogenic process in the lung.</description><identifier>ISSN: 1792-0981</identifier><identifier>EISSN: 1792-1015</identifier><identifier>DOI: 10.3892/etm.2015.2870</identifier><identifier>PMID: 26889224</identifier><language>eng</language><publisher>Greece: D.A. Spandidos</publisher><subject>adenomatous hyperplasia ; Analysis ; array-comparative genomic hybridization ; Care and treatment ; Case reports ; Cell cycle ; chromosome abnormalities ; Chromosomes ; Complications and side effects ; CT imaging ; Deoxyribonucleic acid ; Development and progression ; DNA ; Genetic testing ; Hybridization ; Hypotheses ; Immunohistochemistry ; Lung cancer ; multi-step progression ; Pathogenesis</subject><ispartof>Experimental and therapeutic medicine, 2016-01, Vol.11 (1), p.98-100</ispartof><rights>Copyright: © Bettio et al.</rights><rights>COPYRIGHT 2016 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2016</rights><rights>Copyright: © Bettio et al. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c512t-4e97355efc7bf2e588395f1ef2c4203b4894afe7844f2367748c626d201097bc3</citedby><cites>FETCH-LOGICAL-c512t-4e97355efc7bf2e588395f1ef2c4203b4894afe7844f2367748c626d201097bc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726878/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726878/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26889224$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BETTIO, DANIELA</creatorcontrib><creatorcontrib>VENCI, ANNA</creatorcontrib><creatorcontrib>ACHILLE, VALENTINA</creatorcontrib><creatorcontrib>ALLOISIO, MARCO</creatorcontrib><creatorcontrib>SANTORO, ARMANDO</creatorcontrib><title>Lung cancer in which the hypothesis of multi-step progression is confirmed by array-CGH results: A case report</title><title>Experimental and therapeutic medicine</title><addtitle>Exp Ther Med</addtitle><description>The pathogenesis of lung cancer has not been fully elucidated and biological markers acting as predictors of tumor evolution and aggressiveness remain unidentified. The multi-step hypothesis, suggesting a progression from adenomatous hyperplasia (AAH) to adenocarcinoma (AC) through bronchioalveolar carcinoma (BAC), was highlighted in a previous cytogenetic study performed in a single case. The present study reports the results of an array-comparative genomic hybridization (a-CGH) analysis performed on the DNA obtained from the previously reported case that presented AAH, BAC and AC in one lung. The a-CGH results confirm and support the previous cytogenetic observations with new data, clearly supporting the hypothesis of a multi-step carcinogenic process in the lung.</description><subject>adenomatous hyperplasia</subject><subject>Analysis</subject><subject>array-comparative genomic hybridization</subject><subject>Care and treatment</subject><subject>Case reports</subject><subject>Cell cycle</subject><subject>chromosome abnormalities</subject><subject>Chromosomes</subject><subject>Complications and side effects</subject><subject>CT imaging</subject><subject>Deoxyribonucleic acid</subject><subject>Development and progression</subject><subject>DNA</subject><subject>Genetic testing</subject><subject>Hybridization</subject><subject>Hypotheses</subject><subject>Immunohistochemistry</subject><subject>Lung cancer</subject><subject>multi-step progression</subject><subject>Pathogenesis</subject><issn>1792-0981</issn><issn>1792-1015</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNptkcFv2yAUxq1p1Vp1Pe46IU07OgWMDewwKYq6tlKmXrozwhhiqhg8sDflv9_LkmWtVDg84P3ep8f7iuIDwYtKSHptp2FBMakXVHD8prggXNKSwMPb4xlLQc6Lq5yfMKy6IULU74pz2ggop-yiCOs5bJDRwdiEfEC_e296NPUW9bsxQsw-o-jQMG8nX-bJjmhMcZNszj4GBEkTg_NpsB1qd0inpHfl6vYOAQEl-Qtagnq2cB9jmt4XZ05vs706xsvix7ebx9VduX64vV8t16WpCZ1KZiWv6to6w1tHbS1EJWtHrKOGUVy1TEimneWCMUerhnMmTEObDmaBJW9NdVl8PeiOcwutGRumpLdqTH7Qaaei9uplJvhebeIvxTjMhgsQ-HQUSPHnbPOknuKcAvSsiKwIrmQlyX9qo7dW-eAiiJnBZ6OWjDHMGtJgoBavULA7O3gYn3Ue3l8UlIcCk2LOybpT4wSrvfEKjFd749XeeOA_Pv_tif5nMwCfD0Aedeh8F_OJuXn8XmLYf4X-ACeXtJA</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>BETTIO, DANIELA</creator><creator>VENCI, ANNA</creator><creator>ACHILLE, VALENTINA</creator><creator>ALLOISIO, MARCO</creator><creator>SANTORO, ARMANDO</creator><general>D.A. 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| subjects | adenomatous hyperplasia Analysis array-comparative genomic hybridization Care and treatment Case reports Cell cycle chromosome abnormalities Chromosomes Complications and side effects CT imaging Deoxyribonucleic acid Development and progression DNA Genetic testing Hybridization Hypotheses Immunohistochemistry Lung cancer multi-step progression Pathogenesis |
| title | Lung cancer in which the hypothesis of multi-step progression is confirmed by array-CGH results: A case report |
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