Tubastatin A, an HDAC6 inhibitor, alleviates stroke-induced brain infarction and functional deficits: potential roles of α-tubulin acetylation and FGF-21 up-regulation

Histone deacetylase (HDAC) 6 exists exclusively in cytoplasm and deacetylates cytoplasmic proteins such as α-tubulin. HDAC6 dysfunction is associated with several pathological conditions in the central nervous system. This study investigated the beneficial effects of tubastatin A (TubA), a novel spe...

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Veröffentlicht in:	Scientific reports 2016-01, Vol.6 (1), p.19626, Article 19626
Hauptverfasser:	Wang, Zhifei, Leng, Yan, Wang, Junyu, Liao, Hsiao-Mei, Bergman, Joel, Leeds, Peter, Kozikowski, Alan, Chuang, De-Maw
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/106 13/51 13/95 631/378/1689/534 692/308/1426 82 82/29 Acetylation Animals Brain Infarction - drug therapy Brain Infarction - genetics Brain Infarction - metabolism Brain Infarction - physiopathology Cell Death - drug effects Disease Models, Animal Fibroblast Growth Factors - genetics Fibroblast Growth Factors - metabolism Gene Expression Regulation Glutamic Acid - metabolism Histone Deacetylase Inhibitors - pharmacology Humanities and Social Sciences Hydroxamic Acids - pharmacology Indoles - pharmacology Mitochondria - drug effects Mitochondria - metabolism multidisciplinary Neurites - metabolism Neurons - drug effects Neurons - metabolism Neuroprotective Agents - pharmacology Rats Recovery of Function - drug effects Science Signal Transduction - drug effects Tubulin - metabolism Up-Regulation - drug effects
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