Inhibiting the immunoproteasome exacerbates the pathogenesis of systemic Candida albicans infection in mice

Apart from its role in MHC class I antigen processing, the immunoproteasome has recently been implicated in the modulation of T helper cell differentiation under polarizing conditions in vitro and in the pathogenesis of autoimmune diseases in vivo . In this study, we investigated the influence of LM...

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Veröffentlicht in:	Scientific reports 2016-01, Vol.6 (1), p.19434-19434, Article 19434
Hauptverfasser:	Mundt, Sarah, Basler, Michael, Buerger, Stefanie, Engler, Harald, Groettrup, Marcus
Format:	Artikel
Sprache:	eng
Schlagworte:	692/699/1585/1681 692/699/255 Animal models Animals Antifungal Agents - administration & dosage Antifungal Agents - pharmacology Antigen processing Autoimmune diseases Candida albicans - drug effects Candida albicans - immunology Candidiasis Candidiasis - immunology Candidiasis - metabolism Candidiasis - microbiology Candidiasis - mortality Cell differentiation Colony Count, Microbial Cytokines - biosynthesis Disease Models, Animal Genes Helper cells Humanities and Social Sciences Humans Immunity, Innate Immunomodulation - drug effects Inflammation Interferon Kidney Kidneys Leukocyte Count Leukocytes (mononuclear) Leukocytes, Mononuclear - immunology Leukocytes, Mononuclear - metabolism Lymphocytes T Major histocompatibility complex Mice multidisciplinary Neutrophil Infiltration Neutrophils - immunology Neutrophils - pathology Oligopeptides - pharmacology Pathogenesis Peripheral blood mononuclear cells Proteasome Endopeptidase Complex - metabolism Proteasome Inhibitors - pharmacology Rodents Science Spleen - immunology Spleen - metabolism Spleen - microbiology Spleen - pathology Splenocytes T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism
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