Isolation of highly enriched primary human microglia for functional studies

Microglia, the resident macrophages of the central nervous system play vital roles in brain homeostasis through clearance of pathogenic material. Microglia are also implicated in neurological disorders through uncontrolled activation and inflammatory responses. To date, the vast majority of microgli...

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Veröffentlicht in:	Scientific reports 2016-01, Vol.6 (1), p.19371-19371, Article 19371
Hauptverfasser:	Rustenhoven, Justin, Park, Thomas I-H, Schweder, Patrick, Scotter, John, Correia, Jason, Smith, Amy M., Gibbons, Hannah M., Oldfield, Robyn L., Bergin, Peter S., Mee, Edward W., Faull, Richard L. M., Curtis, Maurice A., Scott Graham, E., Dragunow, Mike
Format:	Artikel
Sprache:	eng
Schlagworte:	13/51 631/378/87 692/308/1426 Animal models Autopsy Biomarkers Biopsy Brain Cell culture Cell Separation - methods Cells, Cultured Central nervous system Chemokines - biosynthesis Culture media Cytokines - biosynthesis Gene expression Gene Expression Regulation Homeostasis Humanities and Social Sciences Humans Immunohistochemistry Inflammation Interleukin-1beta - metabolism Macrophages Microglia Microglia - cytology Microglia - physiology multidisciplinary Neurological diseases NF-kappa B - metabolism Phagocytes Phagocytosis Phenotype Protein Transport Rodents Science Secretions Secretome Transcriptomes
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