miRNA-378 reverses chemoresistance to cisplatin in lung adenocarcinoma cells by targeting secreted clusterin

Cisplatin resistance is a major obstacle in the treatment of NSCLC and its mechanism has not been fully elucidated. The objectives of the study were to determine the role of miR-378 in the sensitivity of lung adenocarcinoma cells to cisplatin (cDDP) and its working mechanism. With TargetScan and luc...

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Veröffentlicht in:	Scientific reports 2016-01, Vol.6 (1), p.19455-19455, Article 19455
Hauptverfasser:	Chen, Xuesong, Jiang, Ying, Huang, Zheping, Li, Dandan, Chen, Xiaodi, Cao, Mengru, Meng, Qingwei, Pang, Hui, Sun, Lichun, Zhao, Yanbin, Cai, Li
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337/384/331 692/699/67/1059/2326 Adenocarcinoma Adenocarcinoma - drug therapy Adenocarcinoma - genetics Adenocarcinoma - pathology Adenocarcinoma of Lung Animal models Animals Apoptosis Apoptosis - drug effects Apoptosis - genetics Binding sites Cancer therapies Cell cycle Cell Line, Tumor Chemoresistance Cisplatin Cisplatin - pharmacology Clusterin Clusterin - chemistry Clusterin - genetics Disease Models, Animal Drug Resistance, Neoplasm - genetics Female Gene expression Gene Expression Regulation, Neoplastic Humanities and Social Sciences Humans Lung cancer Lung Neoplasms - drug therapy Lung Neoplasms - genetics Lung Neoplasms - pathology Lungs Mice, Nude MicroRNAs MicroRNAs - chemistry MicroRNAs - genetics miRNA multidisciplinary Non-small cell lung carcinoma RNA Interference Science Tumors Xenograft Model Antitumor Assays Xenografts
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